TGF-β and retinoic acid induce the microRNA miR-10a, which targets Bcl-6 and constrains the plasticity of helper T cells
- 29 April 2012
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature Immunology
- Vol. 13 (6), 587-595
- https://doi.org/10.1038/ni.2286
Abstract
Polarized CD4+ T cells can demonstrate considerable plasticity depending on the cytokine milieu they encounter. O'Shea and colleagues show that retinoic acid induces the microRNA miR-10a, which suppresses the transcription factor Bcl-6 to prevent conversion into follicular helper T cells. Distinct CD4+ T cell subsets are critical for host defense and immunoregulation. Although these subsets can act as terminally differentiated lineages, they have been increasingly noted to demonstrated plasticity. MicroRNAs are factors that control T cell stability and plasticity. Here we report that naturally occurring regulatory T cells (Treg cells) had high expression of the microRNA miR-10a and that miR-10a was induced by retinoic acid and transforming growth factor-β (TGF-β) in inducible Treg cells. By simultaneously targeting the transcriptional repressor Bcl-6 and the corepressor Ncor2, miR-10a attenuated the phenotypic conversion of inducible Treg cells into follicular helper T cells. We also found that miR-10a limited differentiation into the TH17 subset of helper T cells and therefore represents a factor that can fine-tune the plasticity and fate of helper T cells.Keywords
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