Distinct Expression Patterns of E-Cadherin and β-Catenin in Signet Ring Cell Carcinoma Components of Primary Pulmonary Adenocarcinoma
Open Access
- 1 September 2006
- journal article
- Published by Archives of Pathology and Laboratory Medicine in Archives of Pathology & Laboratory Medicine
- Vol. 130 (9), 1320-1325
- https://doi.org/10.5858/2006-130-1320-depoea
Abstract
Context.—E-Cadherin and β-catenin complexes have been suggested to have critical roles in cancer development and progression. Primary signet ring cell carcinoma (SRCC) of the lung is a rare variant of pulmonary adenocarcinoma, and E-cadherin and β-catenin expressions of this tumor have not been documented, to our knowledge. Objective.—To characterize the E-cadherin and β-catenin expressions in SRCC of the lung. Design.—An immunohistochemical evaluation of E-cadherin and β-catenin expressions in 10 cases of SRCC of the lung, 10 cases of conventional pulmonary adenocarcinoma, 10 cases of gastric SRCC, and 10 cases of colorectal SRCC was performed. Results.—Membranous E-cadherin and β-catenin expressions were frequently reduced or absent in all types of tumors tested. Aberrant E-cadherin localization and nuclear β-catenin accumulation were frequently found in gastric (6/10 and 5/10, respectively) and colorectal (7/10 and 9/ 10, respectively) SRCCs, whereas SRCC of the lung rarely showed aberrant E-cadherin localization (1/10) or nuclear β-catenin accumulation (0/10). Conclusions.—Signet ring cell carcinoma of the lung rarely showed aberrant E-cadherin localization or β-catenin nuclear accumulation, which are frequent events in gastric and colorectal SRCCs. These results suggest that the biologic roles of E-cadherin and β-catenin complexes in SRCC of the lung differ from their roles in gastric or colorectal SRCCs.Keywords
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