Unique form of propriospinal myoclonus as a possible complication of an enteropathogenic toxin
- 28 March 2003
- journal article
- case report
- Published by Wiley in Movement Disorders
- Vol. 18 (8), 942-948
- https://doi.org/10.1002/mds.10453
Abstract
Propriospinal myoclonus is an uncommon form of spinal myoclonus propagated, presumably, by slowly conducting polysynaptic intraspinal pathways. Although most patients demonstrate no clear etiology, a variety of disorders have been linked to this abnormal movement, including trauma, multiple sclerosis, tumors, and infectious disorders such as herpes zoster, human immunodeficiency virus, and Lyme disease. We describe 2 young male patients from the same town in Northern Ontario, Canada, exposed to an outbreak of Escherichia coli O157:H7 from contaminated municipal water, who developed identical clinical and electrophysiological features suggestive of a rhythmic form of propriospinal myoclonus with activity alternating between abdominal and paraspinal muscles. A toxin‐mediated microvascular thrombosis is proposed as a possible pathogenic mechanism underlying this novel association. © 2003 Movement Disorder SocietyKeywords
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