Correlation analysis between genome-wide expression profiles and cytoarchitectural abnormalities in the prefrontal cortex of psychiatric disorders
- 2 September 2008
- journal article
- research article
- Published by Springer Science and Business Media LLC in Molecular Psychiatry
- Vol. 15 (3), 326-336
- https://doi.org/10.1038/mp.2008.99
Abstract
Cytoarchitectural abnormalities have been described in the prefrontal cortex of subjects with schizophrenia, bipolar disorder and depression. However, little is known about the gene expression profiles associated with these abnormalities. Genome-wide expression profiling technology provides an unbiased approach to identifying candidate genes and biological processes that may be associated with complex biological traits such as cytoarchitecture. In this study, we explored expression profiles associated with the abnormalities by using publicly available microarray metadata and cytoarchitectural data from post-mortem samples of the frontal cortex from 54 subjects (schizophrenia, n=14; bipolar disorder, n=13; depression, n=12 and controls n=15). Correlation analysis between genome-wide expression levels and cytoarchitectural traits revealed that 818 genes were significantly correlated with a decrease in the number of perineuronal oligodendrocytes across all subjects. A total of 600 genes were significantly correlated with a decrease in density of calbindin-positive interneurons across all subjects. Multiple biological processes including cellular metabolism, central nervous system development, cell motility and programmed cell death were significantly overrepresented in both correlated gene lists. These findings may provide novel insights into the molecular mechanisms that underlie the cytoarchitectural abnormalities of perineuronal oligodendrocytes and calbindin-containing GABAergic interneurons in the prefrontal cortex of the major psychiatric disorders.Keywords
This publication has 39 references indexed in Scilit:
- Genetic Networks of Liver Metabolism Revealed by Integration of Metabolic and Transcriptional ProfilingPLoS Genetics, 2008
- Gene expression profiling in a mouse model of infantile neuronal ceroid lipofuscinosis reveals upregulation of immediate early genes and mediators of the inflammatory responseBMC Neuroscience, 2007
- Suicide candidate genes associated with bipolar disorder and schizophrenia: An exploratory gene expression profiling analysis of post-mortem prefrontal cortexBMC Genomics, 2007
- Survival prediction of stage I lung adenocarcinomas by expression of 10 genesJCI Insight, 2007
- Expression of oligodendrocyte-associated genes in dorsolateral prefrontal cortex of patients with schizophreniaSchizophrenia Research, 2007
- Effect of Chronic Antipsychotic Exposure on Astrocyte and Oligodendrocyte Numbers in Macaque MonkeysBiological Psychiatry, 2007
- Combined Application of Behavior Genetics and Microarray Analysis to Identify Regional Expression Themes and Gene–Behavior AssociationsJournal of Neuroscience, 2006
- Mitochondrial dysfunction in schizophrenia: evidence for compromised brain metabolism and oxidative stressMolecular Psychiatry, 2004
- Mitochondrial dysfunction in schizophrenia: evidence for compromised brain metabolism and oxidative stressMolecular Psychiatry, 2004
- A Biometrics Invited Paper. The Analysis and Selection of Variables in Linear RegressionPublished by JSTOR ,1976