Proportions of CD4+ memory T cells are altered in individuals chronically infected with Schistosoma haematobium
Open Access
- 26 June 2012
- journal article
- research article
- Published by Springer Science and Business Media LLC in Scientific Reports
- Vol. 2 (1), 472
- https://doi.org/10.1038/srep00472
Abstract
Characterisation of protective helminth acquired immunity in humans or experimental models has focused on effector responses with little work conducted on memory responses. Here we show for the first time, that human helminth infection is associated with altered proportions of the CD4+ memory T cells, with an associated alteration of TH1 responses. The reduced CD4+ memory T cell proportions are associated with a significantly lower ratio of schistosome-specific IgE/IgG4 (marker for resistance to infection/re-infection) in uninfected older people. Helminth infection does not affect the CD8+ memory T cell pool. Furthermore, we show for the first time in a helminth infection that the CD4+ memory T cell proportions decline following curative anti-helminthic treatment despite increased CD4+ memory cell replication. Reduced accumulation of the CD4+ memory T cells in schistosome-infected people has implications for the development of natural or vaccine induced schistosome-specific protective immunity as well as for unrelated pathogens.This publication has 64 references indexed in Scilit:
- Exposure, infection, systemic cytokine levels and antibody responses in young children concurrently exposed to schistosomiasis and malariaParasitology, 2011
- Vaccines to combat the neglected tropical diseasesImmunological Reviews, 2010
- Acquired immune heterogeneity and its sources in human helminth infectionParasitology, 2010
- Helminth secretions induce de novo T cell Foxp3 expression and regulatory function through the TGF-β pathwayThe Journal of Experimental Medicine, 2010
- Increases in Levels of Schistosome‐Specific Immunoglobulin E and CD23+B Cells in a Cohort of Kenyan Children Undergoing Repeated Treatment and Reinfection withSchistosoma mansoniThe Journal of Infectious Diseases, 2010
- Generation, persistence and plasticity of CD4 T‐cell memoriesImmunology, 2010
- Memory CD4 T cells: generation, reactivation and re‐assignmentImmunology, 2010
- CD4 memory T cells divide poorly in response to antigen because of their cytokine profileProceedings of the National Academy of Sciences of the United States of America, 2008
- Evidence for HIV-associated B cell exhaustion in a dysfunctional memory B cell compartment in HIV-infected viremic individualsThe Journal of Experimental Medicine, 2008
- Immune Regulation by helminth parasites: cellular and molecular mechanismsNature Reviews Immunology, 2003