Tumor budding correlates with poor prognosis and epithelial-mesenchymal transition in tongue squamous cell carcinoma
- 12 April 2011
- journal article
- research article
- Published by Wiley in Journal of Oral Pathology & Medicine
- Vol. 40 (7), 545-551
- https://doi.org/10.1111/j.1600-0714.2011.01041.x
Abstract
J Oral Pathol Med (2011) 40: 545–551 Background: Tumor budding is a readily detectable histopathological feature and has been recognized as an adverse prognostic factor in several human cancers. However, the prognostic value of tumor budding in tongue squamous cell carcinoma (TSCC) has not been reported. The purpose of this study was to assess the correlation of tumor budding with the clinicopathologic features, and the known molecular biomarkers (E‐cadherin and Vimentin), as well as to evaluate its prognostic significance for TSCC. Methods: Archival clinical samples of 230 patients with TSCC were examined for tumor budding. Immunohistochemistry analyses were performed to examine the expression of E‐cadherin and Vimentin. Statistical analyses were carried out to assess the correlation of tumor budding with clinicopathologic parameters and patient survival. The potential association between tumor budding and alterations of E‐cadherin and Vimentin expression was also assessed. Results: Of the 230 TSCC cases examined, tumor budding was observed in 165 cases (71.7%), with a mean tumor bud count of 7.5 (range from 1 to 48 buds). High‐intensity budding (≥5 tumor buds) was observed in 111 cases (48.3%). Statistical analysis revealed that tumor budding was associated with tumor size (P < 0.05), differentiation (P < 0.05), clinical stage (P < 0.05), lymph node metastasis (P < 0.01), and correlated with reduced overall survival. In addition, significant associations were observed among tumor budding and the deregulation of E‐cadherin (P < 0.001) and Vimentin (P < 0.001). Conclusions: Tumor budding, which associates with epithelial–mesenchymal transition, is a frequent event and appears to be an independent prognostic factor in TSCC.Keywords
This publication has 46 references indexed in Scilit:
- Tumor Budding as a Strong Prognostic Indicator in Invasive Ampullary AdenocarcinomasThe American Journal of Surgical Pathology, 2010
- Histopathologic Features of the Tumor Budding in Adenocarcinoma of the Lung: Tumor Budding As an Index to Predict the Potential AggressivenessJournal of Thoracic Oncology, 2010
- Tumour budding and a low host inflammatory response are associated with a poor prognosis in oesophageal and gastro‐oesophageal junction cancersHistopathology, 2010
- Reproducibility of the Rapid Bud Count Method for Assessment of Tumor Budding in Stage II Colorectal CancerThe American Journal of Surgical Pathology, 2010
- Validation of the Histologic Risk Model in a New Cohort of Patients With Head and Neck Squamous Cell CarcinomaThe American Journal of Surgical Pathology, 2010
- Tumor budding in tumor invasive front predicts prognosis and survival of patients with esophageal squamous cell carcinomas receiving neoadjuvant chemotherapyCancer, 2009
- Multivariate Analysis of the Pathologic Features of Esophageal Squamous Cell Cancer: Tumor Budding Is a Significant Independent Prognostic FactorAnnals of Surgical Oncology, 2008
- Tumour budding at invasive margins and outcome in colorectal cancerColorectal Disease, 2007
- The high prognostic value of the histologic grade at the deep invasive front of tongue squamous cell carcinomaJournal of Oral Pathology & Medicine, 2005