Suppression of an Established Immune Response by UVA— A Critical Role for Mast Cells
- 4 August 2007
- journal article
- Published by Wiley in Photochemistry and Photobiology
- Vol. 83 (5), 1095-1100
- https://doi.org/10.1111/j.1751-1097.2007.00184.x
Abstract
Exposing experimental animals or human volunteers to UVA II (320–340 nm) radiation after immunization suppresses immunologic memory and the elicitation of delayed‐in‐time hypersensitivity reactions. Previous studies indicated that the mechanisms underlying UVA‐induced immune suppression are similar to those described for UVB‐induced immune suppression, i.e. transferred by T regulatory cells, overcome by repairing DNA damage, neutralizing interleukin (IL)‐10 activity, or injecting recombinant IL‐12. Here we continued our examination of the mechanisms involved in UVA II‐induced suppression. Antibodies to cis‐urocanic acid blocked UVA‐induced immune suppression. Treating UVA‐irradiated mice with histamine receptor antagonists, calcitonin gene‐related peptide (CGRP) receptor antagonists or platelet activating factor receptor antagonists blocked immune suppression in UVA‐irradiated mice. In light of the fact that cis‐urocanic acid and CGRP target mast cells, which can then release platelet activating factor and histamine, we measured UVA‐induced immune suppression in mast cell‐deficient mice. No immune suppression was noted in UVA‐irradiated mast cell‐deficient mice. These findings indicate that exposure to UVA II activates many of the same immune regulatory factors activated by UVB to induce immune suppression. Moreover, they indicate that mast cells play a critical role in UVA‐induced suppression of secondary immune reactions.Keywords
This publication has 43 references indexed in Scilit:
- Cis-urocanic acid, a sunlight-induced immunosuppressive factor, activates immune suppression via the 5-HT2AreceptorProceedings of the National Academy of Sciences, 2006
- Platelet-Activating Factor Is Crucial in Psoralen and Ultraviolet A-Induced Immune Suppression, Inflammation, and ApoptosisThe American Journal of Pathology, 2006
- Association between melanoma and dermal mast cell prevalence in sun-unexposed skinBritish Journal of Dermatology, 2004
- Platelet activating factor receptor binding plays a critical role in jet fuel-induced immune suppressionToxicology and Applied Pharmacology, 2004
- Mechanisms Underlying the Suppression of Established Immune Responses by Ultraviolet RadiationJournal of Investigative Dermatology, 2002
- Ultraviolet A Radiation Suppresses an Established Immune Response: Implications for Sunscreen DesignJournal of Investigative Dermatology, 2001
- ACTION SPECTRA FOR THE trans TO cis PHOTOISOMERISATION OF UROCANIC ACID in vitro and IN MOUSE SKINPhotochemistry and Photobiology, 1993
- SUPPRESSION OF THE INDUCTION OF DELAYED‐TYPE HYPERSENSITIVITY REACTIONS IN MICE BY A SINGLE EXPOSURE TO ULTRAVIOLET RADIATIONPhotochemistry and Photobiology, 1986
- SUPPRESSION OF CONTACT HYPERSENSITIVITY BY UV RADIATION AND ITS RELATIONSHIP TO UV-INDUCED SUPPRESSION OF TUMOR IMMUNITYPhotochemistry and Photobiology, 1981
- SUPPRESSION OF CONTACT HYPERSENSITIVITY BY UV RADIATION AND ITS RELATIONSHIP TO UV-INDUCED SUPPRESSION OF TUMOR IMMUNITYPhotochemistry and Photobiology, 1981