Expression of p53 Tumor Suppressor Protein in Sun-exposed Skin and Associations with Sunscreen Use and Time Spent Outdoors: A Community-based Study
Open Access
- 19 April 2006
- journal article
- research article
- Published by Oxford University Press (OUP) in American Journal of Epidemiology
- Vol. 163 (11), 982-988
- https://doi.org/10.1093/aje/kwj137
Abstract
The p53 gene is a tumor suppressor gene that is commonly mutated in skin cancer and sun-exposed skin, and this can be detected through immunohistochemical expression of the p53 protein. The authors hypothesized that time spent outdoors is associated with p53 protein expression in human skin and that sunscreen use counteracts the association. In 1996, they investigated this in a community-based cross-sectional study in Australia. Detailed information about skin type, time spent outdoors, and sunscreen use was collected from 139 residents of a subtropical township who also provided a skin biopsy from the back of the hand for measurement of p53 expression. Increasing time spent outdoors was positively associated with immunoreactivity in the whole epidermis and in the basal layer of the epidermis. After adjustment for confounders, p53 immunoreactivity was twice as high for people who used sunscreen 1 or 2 days per week as for those who used sunscreen daily (whole epidermis: ratio estimate = 2.0, 95% confidence interval: 1.1, 3.6; basal layer: ratio estimate = 1.7, 95% confidence interval: 0.9, 3.1). The authors conclude that p53 immunoreactivity in the skin is a marker of exposure to ultraviolet light in the past 6 months, but this may be mitigated by regular application of sunscreen.Keywords
This publication has 24 references indexed in Scilit:
- The Origin of CancerPublished by Oxford University Press (OUP) ,2008
- The effect of ultraviolet (UV) A1, UVB and solar-simulated radiation on p53 activation and p21Waf1/Cip1British Journal of Dermatology, 2005
- P53 and PrognosisNew Insights and Further ComplexityCell, 2005
- Mutation spectra of epidermal p53 clones adjacent to basal cell carcinoma and squamous cell carcinomaExperimental Dermatology, 2004
- The expression of p53, p21, Bax and induction of apoptosis in normal volunteers in response to different doses of ultraviolet radiationBritish Journal of Dermatology, 2002
- Carcinogenesis of basal cell carcinomas: genetics and molecular mechanismsBritish Journal of Dermatology, 2002
- p53 expression and risk factors for cutaneous melanoma: A case-control studyInternational Journal of Cancer, 1998
- Sunlight and carcinogenesis: Expression ofp53 and pyrimidine dimers in human skin following UVA I, UVA I + II and solar simulating radiationsInternational Journal of Cancer, 1998
- p53 Mutations Are Common and Early Events that Precede Tumor Invasion in Squamous Cell Neoplasia of the SkinJournal of Investigative Dermatology, 1993
- p53, guardian of the genomeNature, 1992