Impact of Serum Retinol-Binding Protein 4 Levels on Regulation of Remnant-Like Particles Triglyceride in Type 2 Diabetes Mellitus
Open Access
- 19 March 2013
- journal article
- research article
- Published by Hindawi Limited in Journal of Diabetes Research
- Vol. 2013, 1-5
- https://doi.org/10.1155/2013/143515
Abstract
Background. Although retinol-binding protein 4 (RBP4) associates with insulin resistance and remnant-like particles triglyceride (RLP-TG) elevated in the insulin resistant state, few data exist regarding the relationship between RBP4 and RLP-TG. Subjects and Methods. The study included 92 Japanese type 2 diabetic mellitus (T2DM) male patients (age years, body mass index (BMI) kg/m2, waist circumference (WC) cm, and HbA1c (NGSP) %). Patients on medications affecting insulin sensitivity, including fibrates, biguanides, and thiazolidinedione, were excluded. Visceral fat area (VFA) and subcutaneous fat area (SFA) were measured by computed tomography. Results. RBP4 levels showed a significant positive correlation with RLP-TG ( and ), TG ( and ), RLP-TG/TG ( and ), and age ( and ), although there was no significant correlation with VFA, SFA, adiponectin levels, or homeostasis model of assessment insulin resistance (HOMA-R). Multiple regression analysis revealed that RBP4 was an independent determinant of RLP-TG () but was not a determinant of TG. Conclusions. RBP4 correlates positively with serum RLP-TG independent of fat accumulation in T2DM. RBP4 may regulate remnant metabolism independent of glycemic control in T2DM.Keywords
This publication has 24 references indexed in Scilit:
- Measurement of serum remnant-like lipoprotein particle-triglyceride (RLP-TG) and RLP-TG/total TG ratio using highly sensitive triglyceride assay reagentClinica Chimica Acta; International Journal of Clinical Chemistry, 2011
- Reassessment of the cutoff values of waist circumference and visceral fat area for identifying Japanese subjects at risk for the metabolic syndromeDiabetes Research and Clinical Practice, 2008
- The Relationship of Serum Lipoprotein Lipase Mass with Fasting Serum Apolipoprotein B-48 and Remnant-like Particle Triglycerides in Type 2 Diabetic PatientsHormone and Metabolic Research, 2007
- Serum Retinol-Binding Protein Is More Highly Expressed in Visceral than in Subcutaneous Adipose Tissue and Is a Marker of Intra-abdominal Fat MassCell Metabolism, 2007
- Retinol-Binding Protein 4 and Insulin Resistance in Lean, Obese, and Diabetic SubjectsNew England Journal of Medicine, 2006
- Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetesNature, 2005
- New Criteria for `Obesity Disease' in JapanCirculation Journal, 2002
- Pre-Heparin Plasma Lipoprotein Lipase Mass: Correlation With Intra-Abdominal Visceral Fat AccumulationHormone and Metabolic Research, 2001
- Retinoid-binding proteins: mediators of retinoid actionBiochemical Journal, 2000
- Retinoids increase human apo C-III expression at the transcriptional level via the retinoid X receptor. Contribution to the hypertriglyceridemic action of retinoids.JCI Insight, 1998