Partial Excision of the Chromosomal Cassette Containing the Methicillin Resistance Determinant Results in Methicillin-SusceptibleStaphylococcus aureus
Open Access
- 1 August 2005
- journal article
- Published by American Society for Microbiology in Journal of Clinical Microbiology
- Vol. 43 (8), 4191-4193
- https://doi.org/10.1128/jcm.43.8.4191-4193.2005
Abstract
We report a detailed characterization of methicillin-susceptible Staphylococcus aureus isolates from five French hospitals negative for both the mecA and the ccrAB loci but positive for the IS431::pUB110::IS431::dcs structure, present in some Staphylococcus cassette chromosome mec (SCCmec) types. The presence of SCCmec-associated elements suggests that this unusual resistant phenotype is due to a partial excision of SCCmec from epidemic methicillin-resistant S. aureus. The hypothesis of a genetic relatedness is strengthened by common sequence and spa types and similar susceptibility patterns.Keywords
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