Parkin‐mediated selective mitochondrial autophagy, mitophagy: Parkin purges damaged organelles from the vital mitochondrial network
Open Access
- 25 February 2010
- journal article
- review article
- Published by Wiley in FEBS Letters
- Vol. 584 (7), 1386-1392
- https://doi.org/10.1016/j.febslet.2010.02.060
Abstract
Cellular homeostasis is linked tightly to mitochondrial functions. Some damage to mitochondrial proteins and nucleic acids can lead to the depolarization of the inner mitochondrial membrane, thereby sensitizing impaired mitochondria for selective elimination by autophagy. Mitochondrial dysfunction is one of the key aspects of the pathobiology of neurodegenerative disease. Parkin, an E3 ligase located in the cytosol and originally discovered as mutated in monogenic forms of Parkinson's disease (PD), was found recently to translocate specifically to uncoupled mitochondria and to induce their autophagy.This publication has 52 references indexed in Scilit:
- Oxidative stress and inflammation in Parkinson's disease: is there a causal link?Experimental Neurology, 2005
- Parkinson's disease: from causes to mechanismsComptes Rendus Biologies, 2004
- Differential function and expression of the viral inhibitor of caspase 8-induced apoptosis (vICA) and the viral mitochondria-localized inhibitor of apoptosis (vMIA) cell death suppressors conserved in primate and rodent cytomegalovirusesVirology, 2003
- Parkin prevents mitochondrial swelling and cytochrome c release in mitochondria-dependent cell deathHuman Molecular Genetics, 2003
- Mitochondrial Fusion in Human Cells Is Efficient, Requires the Inner Membrane Potential, and Is Mediated by MitofusinsMolecular Biology of the Cell, 2002
- α-Synuclein and parkin: coming together of pieces in puzzle of Parkinson's diseaseThe Lancet, 2001
- Dynamin-related Protein Drp1 Is Required for Mitochondrial Division in Mammalian CellsMolecular Biology of the Cell, 2001
- An Unfolded Putative Transmembrane Polypeptide, which Can Lead to Endoplasmic Reticulum Stress, Is a Substrate of ParkinCell, 2001
- Themes and variations on ubiquitylationNature Reviews Molecular Cell Biology, 2001
- Mutations in the parkin gene cause autosomal recessive juvenile parkinsonismNature, 1998