Human Copper Transporters: Mechanism, Role in Human Diseases and Therapeutic Potential
- 21 September 2009
- journal article
- review article
- Published by Taylor & Francis Ltd in Future Medicinal Chemistry
- Vol. 1 (6), 1125-1142
- https://doi.org/10.4155/fmc.09.84
Abstract
Normal copper homeostasis is essential for human growth and development. Copper deficiency, caused by genetic mutations, inadequate diet or surgical interventions, may lead to cardiac hypertrophy, ...Funding Information
- National Institutes of Health (R01 DK071865)
This publication has 106 references indexed in Scilit:
- Regression of copper-deficient heart hypertrophy: reduction in the size of hypertrophic cardiomyocytesThe Journal of Nutritional Biochemistry, 2009
- The soluble metal-binding domain of the copper transporter ATP7B binds and detoxifies cisplatinBiochemical Journal, 2009
- Role of copper transporters in resistance to platinating agentsCancer Chemotherapy and Pharmacology, 2008
- Neonatal Diagnosis and Treatment of Menkes DiseaseThe New England Journal of Medicine, 2008
- Human copper transporter 2 is localized in late endosomes and lysosomes and facilitates cellular copper uptakeBiochemical Journal, 2007
- Vertebrate Ctr1 coordinates morphogenesis and progenitor cell fate and regulates embryonic stem cell differentiationProceedings of the National Academy of Sciences of the United States of America, 2007
- Molecular mechanisms of resistance and toxicity associated with platinating agentsCancer Treatment Reviews, 2007
- X-ray fluorescence microscopy reveals large-scale relocalization and extracellular translocation of cellular copper during angiogenesisProceedings of the National Academy of Sciences of the United States of America, 2007
- Hormonal regulation of the Menkes and Wilson copper-transporting ATPases in human placental Jeg-3 cellsBiochemical Journal, 2007
- Variable response of selected cuproproteins in rat choroid plexus and cerebellum following perinatal copper deficiencyGenes & Nutrition, 2006