An altered and more efficient mechanism of CCR5 engagement contributes to macrophage tropism of CCR5-using HIV-1 envelopes
- 8 June 2010
- journal article
- research article
- Published by Elsevier BV in Virology
- Vol. 404 (2), 269-278
- https://doi.org/10.1016/j.virol.2010.05.006
Abstract
No abstract availableKeywords
This publication has 103 references indexed in Scilit:
- Structure of HIV-1 gp120 with gp41-interactive region reveals layered envelope architecture and basis of conformational mobilityProceedings of the National Academy of Sciences, 2009
- A Quantitative Affinity-Profiling System That Reveals Distinct CD4/CCR5 Usage Patterns among Human Immunodeficiency Virus Type 1 and Simian Immunodeficiency Virus StrainsJournal of Virology, 2009
- Inefficient entry of vicriviroc-resistant HIV-1 via the inhibitor-CCR5 complex at low cell surface CCR5 densitiesVirology, 2009
- Loss of the N-linked glycosylation site at position 386 in the HIV envelope V4 region enhances macrophage tropism and is associated with dementiaVirology, 2007
- Changes in the V3 region of gp120 contribute to unusually broad coreceptor usage of an HIV-1 isolate from a CCR5 Δ32 heterozygoteVirology, 2007
- Mutations in the V3 stem versus the V3 crown and C4 region have different effects on the binding and fusion steps of human immunodeficiency virus type 1 gp120 interaction with the CCR5 coreceptorVirology, 2007
- Macrophage entry mediated by HIV Envs from brain and lymphoid tissues is determined by the capacity to use low CD4 levels and overall efficiency of fusionVirology, 2006
- The HIV Env variant N283 enhances macrophage tropism and is associated with brain infection and dementiaProceedings of the National Academy of Sciences, 2006
- CD4-dependent, antibody-sensitive interactions between HIV-1 and its co-receptor CCR-5Nature, 1996
- Comparative Protein Modelling by Satisfaction of Spatial RestraintsJournal of Molecular Biology, 1993