CD34‐reactive tumors of the skin. An updated review of an ever‐growing list of lesions
- 31 December 2008
- journal article
- correction
- Published by Wiley in Journal of Cutaneous Pathology
- Vol. 36 (1), 89-102
- https://doi.org/10.1111/j.1600-0560.2008.01212.x
Abstract
Over the past few years, a growing number of cutaneous tumors expressing CD34 is being reported. The list contains benign and malignant neoplasms as well as reactive and hamartomatous lesions of diverse lineages of differentiation, including fibroblastic, myofibroblastic, fibrohistiocytic, vascular, neural, adipocytic, smooth muscle, hematopoietic, melanocytic and epithelial. The more frequent diagnostic difficulties are found in spindle cell proliferations, mainly in those of the fibrocytic lineage. In part, this is because of the fact that in this area are, aside to well-defined entities, histologically and clinically diverse, recently reported cutaneous CD34-reactive lesions, whose definitions, limits and relationships are not completely established. The CD34 expression plays a key role in the differential diagnosis of some tumors, such as dermatofibrosarcoma protuberans, epithelioid sarcoma or pleomorphic hyalinizing angiectatic tumor of soft parts, with important therapeutic consequences. In others, as in desmoplastic trichilemmoma, it can help to resolve diagnostic problems in concrete cases. Finally, in many of the CD34-positive lesions, the diagnosis with the hematoxylin and eosin stain is straightforward. However, in all of them, the knowledge of the immunohistochemical profile contributes to our understanding of the cutaneous pathology.Keywords
This publication has 104 references indexed in Scilit:
- Myeloid sarcoma: clinico-pathologic, phenotypic and cytogenetic analysis of 92 adult patientsLeukemia, 2006
- Medallion-like dermal dendrocyte hamartoma: A new clinically and histopathologically distinct lesionJournal of the American Academy of Dermatology, 2004
- Multiple elastofibromasJournal of the American Academy of Dermatology, 2004
- CD34‐positive cellular blue neviNoteJournal of Cutaneous Pathology, 2001
- Nuchal-type fibromaCancer, 1999
- CD34-reactive fibrous papule of the noseJournal of the American Academy of Dermatology, 1996
- Immunohistochemical Study of CD34-Positive Dendritic Cells of Human DermisThe American Journal of Dermatopathology, 1996
- Folliculosebaceous cystic hamartoma: A clinical pathologic studyJournal of the American Academy of Dermatology, 1996
- Dermal dendrocyte hamartoma with stubby white hair: A novel connective tissue hamartoma of infancyJournal of the American Academy of Dermatology, 1995
- Fibrous papule: A tumor of fibrohistiocytic cells that contain factor XIIIaJournal of the American Academy of Dermatology, 1988