Morning rise of blood pressure and subcutaneous small resistance artery structure
- 1 August 2007
- journal article
- Published by Ovid Technologies (Wolters Kluwer Health) in Journal of Hypertension
- Vol. 25 (8), 1698-1703
- https://doi.org/10.1097/hjh.0b013e328172dc41
Abstract
Objectives It has been previously demonstrated that the morning rise (MoR) of blood pressure (BP) may predict major cardiovascular events in hypertensive patients. Structural alterations of small resistance arteries, as evaluated by the tunica media to internal lumen ratio (M/L) of subcutaneous small resistance arteries, may also predict cardiovascular events. Because an increased M/L may amplify the effect of hypertensive stimuli, the present study aimed to evaluate the possible relationships between MoR and M/L in a population of hypertensive patients. Methods Sixty-four patients with essential hypertension were included in the present study. All patients were submitted to a biopsy of subcutaneous fat. Small resistance arteries were dissected and mounted on an isometric myograph, and the M/L was measured. In addition, MoR was calculated from ambulatory blood pressure monitoring (ABPM) according to four previously published different methods (MoR1 to MoR4). Results A statistically significant correlation was observed between M/L and MoR1 (r = 0.52, P < 0.001), MoR2 (r = 0.32, P < 0.01), MoR3 (r = 0.25, P < 0.05) and MoR4 (r = 0.27, P < 0.05), as well as between internal diameter of subcutaneous small arteries and MoR1 (r = −0.45, P < 0.001) and MoR2 (r = −0.28, P < 0.05). Conclusion Our results indicate that subcutaneous small artery structure is related to MoR, possibly because an altered vascular structure may amplify BP changes or, vice versa, because a greater MoR may further damage peripheral vasculature.This publication has 34 references indexed in Scilit:
- Circadian rhythm of blood pressure and the relation to cardiovascular eventsJournal of Hypertension, 2006
- Time for focus on morning hypertension: Pitfall of current antihypertensive medicationAmerican Journal of Hypertension, 2005
- Morning Surge in Blood Pressure as a Predictor of Silent and Clinical Cerebrovascular Disease in Elderly HypertensivesCirculation, 2003
- Circadian variation in cardiovascular events.American Journal of Hypertension, 1999
- Circadian Variation in the Onset of Unstable Angina and Non-Q-Wave Acute Myocardial Infarction (The TIMI III Registry and TIMI IIIB)The American Journal of Cardiology, 1997
- Structure and function of small arteriesPhysiological Reviews, 1990
- Circadian variation in the incidence of sudden cardiac death in the framingham heart study populationThe American Journal of Cardiology, 1987
- Evidence for increased media thickness, increased neuronal amine uptake, and depressed excitation--contraction coupling in isolated resistance vessels from essential hypertensives.Circulation Research, 1987
- Circadian variation in the frequency of sudden cardiac death.Circulation, 1987
- Circadian Variation in the Frequency of Onset of Acute Myocardial InfarctionThe New England Journal of Medicine, 1985