Cadherins as Modulators of Cellular Phenotype
Top Cited Papers
- 1 November 2003
- journal article
- review article
- Published by Annual Reviews in Annual Review of Cell and Developmental Biology
- Vol. 19 (1), 207-235
- https://doi.org/10.1146/annurev.cellbio.19.011102.111135
Abstract
▪ Abstract Cadherins are transmembrane glycoproteins that mediate calcium-dependent cell-cell adhesion. The cadherin family is large and diverse, and proteins are considered to be members of this family if they have one or more cadherin repeats in their extracellular domain. Cadherin family members are the transmembrane components of a number of cellular junctions, including adherens junctions, desmosomes, cardiac junctions, endothelial junctions, and synaptic junctions. Cadherin function is critical in normal development, and alterations in cadherin function have been implicated in tumorigenesis. The strength of cadherin interactions can be regulated by a number of proteins, including the catenins, which serve to link the cadherin to the cytoskeleton. Cadherins have been implicated in a number of signaling pathways that regulate cellular behavior, and it is becoming increasingly clear that integration of information received from cell-cell signaling, cell-matrix signaling, and growth factor signaling determines ultimate cellular phenotype and behavior.Keywords
This publication has 161 references indexed in Scilit:
- Dynamic Interplay between Adhesive and Lateral E-Cadherin DimersMolecular and Cellular Biology, 2002
- Vascular Endothelial Growth Factor Induces Shc Association With Vascular Endothelial CadherinArteriosclerosis, Thrombosis, and Vascular Biology, 2002
- Sensing the environment: a historical perspective on integrin signal transductionNature, 2002
- Desmosomal adhesion: structural basis, molecular mechanism and regulation (Review)Molecular Membrane Biology, 2002
- N-Cadherin Extracellular Repeat 4 Mediates Epithelial to Mesenchymal Transition and Increased MotilityThe Journal of cell biology, 2000
- The transcription factor Snail is a repressor of E-cadherin gene expression in epithelial tumour cellsNature, 2000
- Identification of Plakoglobin Domains Required for Association with N-cadherin and α-CateninOnline Journal of Public Health Informatics, 1995
- Identification of the plakoglobin-binding domain in desmoglein and its role in plaque assembly and intermediate filament anchorage.The Journal of cell biology, 1994
- Demonstration of an Adhering-Junction Molecule (Plakoglobin) in the Autoantigens of Pemphigus Foliaceus and Pemphigus VulgarisThe New England Journal of Medicine, 1989
- Enzymatic dissection of embryonic cell adhesive mechanisms: II. Developmental regulation of an endogenous adhesive system in the chick neural retinaDevelopmental Biology, 1981