A Critical Comparison of Murine Pathology and Epidemiological Data of TCDD, PCB126, and PeCDF
Open Access
- 1 December 2007
- journal article
- research article
- Published by SAGE Publications in Toxicologic Pathology
- Vol. 35 (7), 865-879
- https://doi.org/10.1080/01926230701618516
Abstract
2,3,7,8-Tetrachlorodibenzo- p-dioxin (TCDD, or dioxin) and dioxin-like compounds (DLCs) induce numerous toxicities, including developmental, endocrine, immunological, and multi-organ carcinogenic, in animals and/or humans. Multiple studies completed by the National Toxicology Program (NTP) focused on the effects caused in Harlan Sprague-Dawley rats by specific DLCs, among them the prototypical dioxin, TCDD. Because humans are exposed daily to a combination of DLCs, primarily via ingestion of food, the Toxic Equivalency Factor (TEF) was developed in order to evaluate health hazards caused by these mixtures. Herein we review the pathological effects reported in humans exposed to TCDD; 3,3′,4,4′,5-pentachlorobiphenyl (PCB 126); and 2,3,4,7,8,-pentachlorodibenzofuran (PeCDF) and compare them to similar changes seen in NTP murine studies performed with the same compounds. While there were differences in specific pathologies observed, clear consistency in the target organs affected (liver, oral cavity, cardiovascular system, immune system, thyroid, pancreas, and lung) could be seen in both human studies and rodent toxicity and carcinogenicity investigations.Keywords
This publication has 118 references indexed in Scilit:
- Comparison of chronic toxicity and carcinogenicity of 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin (TCDD) in 2‐year bioassays in female Sprague‐Dawley ratsMolecular Nutrition & Food Research, 2006
- The 2005 World Health Organization Reevaluation of Human and Mammalian Toxic Equivalency Factors for Dioxins and Dioxin-Like CompoundsToxicological Sciences, 2006
- Bone resorption by aryl hydrocarbon receptor-expressing osteoclasts is not disturbed by TCDD in short-term culturesLife Sciences, 2005
- Cancer in US Air Force Veterans of the Vietnam WarJournal of Occupational and Environmental Medicine, 2004
- Involvement of the Xenobiotic Response Element (XRE) in Ah Receptor-mediated Induction of Human UDP-glucuronosyltransferase 1A1Online Journal of Public Health Informatics, 2003
- Potential Human Cancer Risks from Exposure to PCBs: A Tale of Two EvaluationsCritical Reviews in Toxicology, 2003
- Chlorinated Hydrocarbons in Infertile WomenEnvironmental Research, 1999
- Promotion of endometriosis in mice by polychlorinated dibenzo-p-dioxins, dibenzofurans, and biphenyls.Environmental Health Perspectives, 1997
- Mortality of Workers Exposed to Polychlorinated Biphenyls—An UpdateArchives of environmental health, 1987
- Morphological changes in monkeys consuming a diet containing low levels of 2,3,7,8-tetrachlorodibenzo-p-dioxinFood and Cosmetics Toxicology, 1977