An HPLC Method for the Determination of Vitamin B1, Caffeine, Acetylsalicylic Acid, and The Impurities of Salicylic Acid in a Pharmaceutical Preparation
- 1 July 1997
- journal article
- research article
- Published by Taylor & Francis Ltd in Journal of Liquid Chromatography & Related Technologies
- Vol. 20 (13), 2123-2133
- https://doi.org/10.1080/10826079708005570
Abstract
An HPLC method for the determination of Vitamin B1, caffeine, acetylsalicylic acid and salicylic acid in tablets containing all four drugs is reported. After optimization of the variables involved, the method has been characterized and validated in terms of calibration (Standard Addition Methodology), repeatability and selectivity, and finally, applied to the quality control of the final product.Keywords
This publication has 10 references indexed in Scilit:
- Ion-pair reversed-phase high-performance liquid chromatographic method for the separation of a set of unphosphorylated thiamine-related compoundsJournal of Chromatography A, 1993
- Estimation of Performance Characteristics of an Analytical Method Using the Data Set Of The Calibration ExperimentAnalytical Letters, 1993
- Separation of Water-Soluble Vitamins by Reversed-Phase lon-lnteraction--Reagent High-Performance Liquid Chromatography: Application to Multivitamin PharmaceuticalsJournal of Chromatographic Science, 1991
- High Performance Liquid Chromatographic Analysis and Dissolution of Dextropropoxyphene Napsylate with other Analgesics in Capsule FormulationsDrug Development and Industrial Pharmacy, 1990
- Simultaneous High-Performance Liquid Chromatographic Assay of Acetaminophen, Acetylsalicylic Acid, Caffeine, and D-Propoxyphene HydrochlorideAnalytical Letters, 1989
- High-performance liquid chromatography of water-soluble vitamins : II. Simultaneous determinations of vitamins B1, B2, B6 and B12 in pharmaceutical preparationsJournal of Chromatography A, 1987
- Determination of Aspirin by Pre-Column Transacetylation Reaction of 3-Aminophenol and Reversed-Phase High-Performance Liquid Chromatography: Simultaneous Determination of Aspirin, Acetaminophen, and CaffeineJournal of Pharmaceutical Sciences, 1987
- Simultaneous determination of dextropropoxyphene napsylate, caffeine, aspirin and salicylic acid in pharmaceutical preparations by reversed-phase HPLCTalanta, 1984
- Minimisation of salicylic acid formation during preparation of aspirin products for analysis by high-performance liquid chromatographyThe Analyst, 1984
- Simultaneous Quantitation of Acetaminophen, Aspirin, Caffeine, Codeine Phosphate, Phenacetin, and Salicylamide by High-pressure Liquid ChromatographyJournal of Pharmaceutical Sciences, 1980