Gold- and Iodine-Mediated Internal Oxygen Transfer of Nitrone- and Sulfoxide-Functionalized Alkynes
- 20 September 2011
- journal article
- research article
- Published by American Chemical Society (ACS) in The Journal of Organic Chemistry
- Vol. 76 (20), 8488-8494
- https://doi.org/10.1021/jo201347r
Abstract
Intramolecular oxygen transfer of nitrone- and sulfoxide-alkynes was achieved using a catalytic amount of Au(I) and a stoichiometric amount of iodine. The Au(I)-catalyzed cyclization of a nitrone-terminal alkyne afforded a cyclic iminoester, while cyclization of analogous nitrone-internal alkynes yielded aldehyde-enones. The I(2)-mediated cyclization of nitrone-alkynes afforded iodinated γ-lactams and the I(2)-mediated internal redox of the closely related sulfoxide-alkynes gave diketones functionalized with a thoiether.Keywords
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