Organellar Na+/H+ Exchangers: Novel Players in Organelle pH Regulation and Their Emerging Functions
- 30 December 2010
- journal article
- review article
- Published by American Chemical Society (ACS) in Biochemistry
- Vol. 50 (4), 443-450
- https://doi.org/10.1021/bi101082e
Abstract
Mammalian Na+/H+ exchangers (NHEs) play a fundamental role in cellular ion homeostasis. NHEs exhibit an appreciable variation in expression, regulation, and physiological function, dictated by their dynamics in subcellular localization and/or interaction with regulatory proteins. In recent years, a subgroup of NHEs consisting of four isoforms has been identified, and its members predominantly localize to the membranes of the Golgi apparatus and endosomes. These organellar NHEs constitute a family of transporters with an emerging function in the regulation of luminal pH and in intracellular membrane trafficking as expressed, for example, in cell polarity development. Moreover, specific roles of a variety of cofactors, regulating the intracellular dynamics of these transporters, are also becoming apparent, thereby providing further insight into their mechanism of action and overall functioning. Interestingly, organellar NHEs have been related to mental disorders, implying a potential role in the brain, thus expanding the physiological significance of these transporters.Keywords
This publication has 82 references indexed in Scilit:
- The Sodium/Proton Exchanger NHE8 Regulates Late Endosomal Morphology and FunctionMolecular Biology of the Cell, 2010
- A mutation affecting the sodium/proton exchanger, SLC9A6, causes mental retardation with tau depositionBrain, 2010
- The Na+/H+Exchanger NHE6 in the Endosomal Recycling System Is Involved in the Development of Apical Bile Canalicular Surface Domains in HepG2 CellsMolecular Biology of the Cell, 2010
- TRPC3 Regulates Agonist-stimulated Ca2+ Mobilization by Mediating the Interaction between Type I Inositol 1,4,5-Trisphosphate Receptor, RACK1, and Orai1Published by Elsevier BV ,2010
- Secretory Carrier Membrane Protein 2 Regulates Cell-surface Targeting of Brain-enriched Na+/H+ Exchanger NHE5Published by Elsevier BV ,2009
- TRPC3 Controls Agonist-stimulated Intracellular Ca2+ Release by Mediating the Interaction between Inositol 1,4,5-Trisphosphate Receptor and RACK1Published by Elsevier BV ,2008
- SLC9A6 Mutations Cause X-Linked Mental Retardation, Microcephaly, Epilepsy, and Ataxia, a Phenotype Mimicking Angelman SyndromeAmerican Journal of Human Genetics, 2008
- Structural and functional analysis of the Na+/H+ exchangerBiochemical Journal, 2007
- Plasticity-Induced Growth of Dendritic Spines by Exocytic Trafficking from Recycling EndosomesNeuron, 2006
- Angelman syndrome: Mimicking conditions and phenotypesAmerican Journal of Medical Genetics, 2001