Reduced Serum Butyrylcholinesterase Activity Indicates Severe Systemic Inflammation in Critically Ill Patients
Open Access
- 11 February 2015
- journal article
- research article
- Published by Hindawi Limited in Mediators of Inflammation
- Vol. 2015 (1), 1-11
- https://doi.org/10.1155/2015/274607
Abstract
Systemic inflammation is an immune response to a nonspecific insult of either infectious or noninfectious origin and remains a challenge in the intensive care units with high mortality rate. Cholinergic neurotransmission plays an important role in the regulation of the immune response during inflammation. We hypothesized that the activity of butyrylcholinesterase (BChE) might serve as a marker to identify and prognose systemic inflammation. By using a point-of-care-testing (POCT) approach we measured BChE activity in patients with severe systemic inflammation and healthy volunteers. We observed a decreased BChE activity in patients with systemic inflammation, as compared to that of healthy individuals. Furthermore, BChE activity showed an inverse correlation with the severity of the disease. Although hepatic function has previously been found essential for BChE production, we show here that the reduced BChE activity associated with systemic inflammation occurs independently of and is thus not caused by any deficit in liver function in these patients. A POCT approach, used to assess butyrylcholinesterase activity, might further improve the therapy of the critically ill patients by minimizing time delays between the clinical assessment and treatment of the inflammatory process. Hence, assessing butyrylcholinesterase activity might help in early detection of inflammation.Keywords
This publication has 44 references indexed in Scilit:
- Assessment of the value of serum cholinesterase as a liver function test for cirrhotic patientsBiomedical Reports, 2013
- Viscoelastic and aggregometric point‐of‐care testing in patients with septic shock – cross‐links between inflammation and haemostasisActa Anaesthesiologica Scandinavica, 2012
- Butyrylcholinesterase interactions with amylin may protect pancreatic cells in metabolic syndromeJournal of Cellular and Molecular Medicine, 2011
- Sepsis biomarkers: a reviewCritical Care, 2010
- Acute and long-term survival in chronically critically ill surgical patients: a retrospective observational studyCritical Care, 2007
- Elevated butyrylcholinesterase and acetylcholinesterase may predict the development of type 2 diabetes mellitus and Alzheimer’s diseaseMedical Hypotheses, 2007
- Butyrylcholinesterase attenuates amyloid fibril formation in vitroProceedings of the National Academy of Sciences of the United States of America, 2006
- Nicotinic acetylcholine receptor α7 subunit is an essential regulator of inflammationNature, 2002
- Profile of Serum Cholinesterase in Systemic Sepsis Syndrome (Septic Shock) in Intensive Care Unit Patientscclm, 1995
- APACHE IICritical Care Medicine, 1985