Gestation-induced changes in lamotrigine pharmacokinetics: A monotherapy study
- 10 August 2004
- journal article
- Published by Ovid Technologies (Wolters Kluwer Health) in Neurology
- Vol. 63 (3), 571-573
- https://doi.org/10.1212/01.wnl.0000133213.10244.fd
Abstract
The authors describe 12 pregnancies in women with epilepsy using lamotrigine (LTG) monotherapy. A seizure increase in nine pregnancies was probably related to a gradual decline of LTG level-to-dose ratio to 40% of baseline. After delivery, LTG kinetics returned swiftly to baseline, causing toxic side effects in some women. Frequent LTG level monitoring and appropriate dose adjustments are advised in the period before and during pregnancy and after delivery, especially in women on LTG monotherapy.This publication has 8 references indexed in Scilit:
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