The transcription factor Erg is essential for definitive hematopoiesis and the function of adult hematopoietic stem cells
- 25 May 2008
- journal article
- Published by Springer Science and Business Media LLC in Nature Immunology
- Vol. 9 (7), 810-819
- https://doi.org/10.1038/ni.1617
Abstract
Ets-related gene (ERG), which encodes a member of the Ets family of transcription factors, is a potent oncogene. Chromosomal rearrangements involving ERG are found in acute myeloid leukemia, acute lymphoblastic leukemia, Ewing's sarcoma and more than half of all prostate cancers; however, the normal physiological function of Erg is unknown. We did a sensitized genetic screen of the mouse for regulators of hematopoietic stem cell function and report here a germline mutation of Erg. We show that Erg is required for definitive hematopoiesis, adult hematopoietic stem cell function and the maintenance of normal peripheral blood platelet numbers.This publication has 56 references indexed in Scilit:
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