Hooked on fat: the role of lipid synthesis in cancer metabolism and tumour development
Open Access
- 1 November 2013
- journal article
- review article
- Published by The Company of Biologists in Disease Models & Mechanisms
- Vol. 6 (6), 1353-1363
- https://doi.org/10.1242/dmm.011338
Abstract
An increased rate of lipid synthesis in cancerous tissues has long been recognised as an important aspect of the rewired metabolism of transformed cells. However, the contribution of lipids to cellular transformation, tumour development and tumour progression, as well as their potential role in facilitating the spread of cancerous cells to secondary sites, are not yet fully understood. In this article, we review the recent findings that support the importance of lipid synthesis and metabolism in tumorigenesis. Specifically, we explore the role of aberrant lipid biosynthesis in cancer cell migration and invasion, and in the induction of tumour angiogenesis. These processes are crucial for the dissemination of tumour cells and formation of metastases, which constitute the main cause of cancer mortality.Keywords
This publication has 113 references indexed in Scilit:
- Mutant p53 Disrupts Mammary Tissue Architecture via the Mevalonate PathwayCell, 2012
- A Conserved SREBP-1/Phosphatidylcholine Feedback Circuit Regulates Lipogenesis in MetazoansCell, 2011
- Effects of Lysophospholipids on Tumor MicroenvironmentCancer Microenvironment, 2011
- Linking Lipid Metabolism to the Innate Immune Response in Macrophages through Sterol Regulatory Element Binding Protein-1aCell Metabolism, 2011
- AMPK Phosphorylates and Inhibits SREBP Activity to Attenuate Hepatic Steatosis and Atherosclerosis in Diet-Induced Insulin-Resistant MiceCell Metabolism, 2011
- Genome-wide Localization of SREBP-2 in Hepatic Chromatin Predicts a Role in AutophagyCell Metabolism, 2011
- Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1Molecular Cell, 2010
- Monoacylglycerol Lipase Regulates a Fatty Acid Network that Promotes Cancer PathogenesisCell, 2010
- SREBP Activity Is Regulated by mTORC1 and Contributes to Akt-Dependent Cell GrowthCell Metabolism, 2008
- Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase PathwayMolecular Cell, 2008