Plasma Protein Binding of d‐Propoxyphene in Normal Subjects and Anephric Patients
- 3 February 1978
- journal article
- Published by Wiley in The Journal of Clinical Pharmacology
- Vol. 18 (2-3), 106-109
- https://doi.org/10.1002/j.1552-4604.1978.tb02429.x
Abstract
The free fraction of d-propoxyphene in the plasma of normal subjects is 0.24 +/- 0.02 (mean +/- S.D.) and is not concentration dependent in the usual therapeutic and toxic conentration range. Renal failure and relatively high concentrations of d-norpropoxyphene, the major metabolite of d-propoxyphene, have no significant effect on the plasma protein binding of d-propoxyphene.Keywords
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