Increased Risk of Pancreatic Cancer in Melanoma-Prone Kindreds withp16INK4Mutations
Open Access
- 12 October 1995
- journal article
- research article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 333 (15), 970-975
- https://doi.org/10.1056/nejm199510123331504
Abstract
A gene on chromosome 9p, p16INK4, has been implicated in the pathogenesis of cutaneous malignant melanoma in 19 melanoma-prone families. In 10 of these kindreds mutations that impaired the function of the p16 INK4 protein (p16M alleles) cosegregated with the disease. By contrast, in the other nine kindreds the mutation did not alter the function of p16 INK4 (p16W alleles). We looked for differences in clinical and genetic epidemiologic features in these two groups of families.This publication has 19 references indexed in Scilit:
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