Regulation of microRNA biogenesis
Top Cited Papers
- 16 July 2014
- journal article
- review article
- Published by Springer Science and Business Media LLC in Nature Reviews Molecular Cell Biology
- Vol. 15 (8), 509-524
- https://doi.org/10.1038/nrm3838
Abstract
MicroRNAs (miRNAs) are small non-coding RNAs that function as guide molecules in RNA silencing. Targeting most protein-coding transcripts, miRNAs are involved in nearly all developmental and pathological processes in animals. The biogenesis of miRNAs is under tight temporal and spatial control, and their dysregulation is associated with many human diseases, particularly cancer. In animals, miRNAs are ∼22 nucleotides in length, and they are produced by two RNase III proteins--Drosha and Dicer. miRNA biogenesis is regulated at multiple levels, including at the level of miRNA transcription; its processing by Drosha and Dicer in the nucleus and cytoplasm, respectively; its modification by RNA editing, RNA methylation, uridylation and adenylation; Argonaute loading; and RNA decay. Non-canonical pathways for miRNA biogenesis, including those that are independent of Drosha or Dicer, are also emerging.Keywords
This publication has 161 references indexed in Scilit:
- DNA-Damage-Induced Nuclear Export of Precursor MicroRNAs Is Regulated by the ATM-AKT PathwayCell Reports, 2013
- Molecular Basis for Interaction of let-7 MicroRNAs with Lin28Cell, 2011
- Phosphorylation of the Human MicroRNA-Generating Complex Mediates MAPK/Erk SignalingCell, 2009
- Origin, Biogenesis, and Activity of Plant MicroRNAsCell, 2009
- MicroRNAs: Target Recognition and Regulatory FunctionsCell, 2009
- Posttranscriptional Crossregulation between Drosha and DGCR8Cell, 2009
- Targeted Deletion Reveals Essential and Overlapping Functions of the miR-17∼92 Family of miRNA ClustersCell, 2008
- Sorting of Drosophila Small Silencing RNAsCell, 2007
- Drosophila microRNAs Are Sorted into Functionally Distinct Argonaute Complexes after Production by Dicer-1Cell, 2007
- The Mirtron Pathway Generates microRNA-Class Regulatory RNAs in DrosophilaCell, 2007