Efficient and facile formation of two-component nanoparticles via aromatic moiety directed self-assembly
- 26 April 2011
- journal article
- Published by Royal Society of Chemistry (RSC) in Chemical Communications
- Vol. 47 (37), 10224-10226
- https://doi.org/10.1039/c1cc11048a
Abstract
Here we present a two-component self-assembling system employing the interaction of aromatic groups (Fmoc) to construct nanoparticles. Spherical particles of around 70 nm were formed spontaneously by a simple trigonal Fmoc-conjugate, which were then stabilized by Fmoc-dipeptides at physiological pH in aqueous solution. These novel particles, being well-tolerated by cells, capable of encapsulating hydrophobic compounds, and readily decorated by short peptides, are promising carriers for drug delivery.Keywords
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