Blood Pressure, Renal Function, and Proteinuria in Children with Unilateral Renal Agenesis
- 1 November 2006
- journal article
- Published by S. Karger AG in Kidney and Blood Pressure Research
- Vol. 29 (4), 210-215
- https://doi.org/10.1159/000095735
Abstract
Background/Aim: Unilateral renal agenesis (URA) is a model for a reduced nephron number that is believed to be a risk factor for blood pressure (BP) elevation and reduced renal function. The aim of the study was to investigate BP and renal function in children with URA. Methods: Data on children with URA from two pediatric nephrology centers were firstly retrospectively reviewed (renal ultrasound and scintigraphy, clinical BP, creatinine clearance, urinalysis). Children with normal renal ultrasound and scintigraphy were thereafter investigated using ambulatory BP monitoring. Results: Twenty-nine children with URA were investigated – 14 children with an abnormal kidney (mostly scarring) and 15 children with healthy kidneys. Hypertension was diagnosed on the basis of clinical BP in 57% of the children with abnormal kidneys and on the basis of ambulatory BP monitoring in 1 child (7%) with healthy kidneys. The mean ambulatory BP in children with normal kidneys was not significantly different from that in controls. Forty-three percent of the children with abnormal kidneys had a reduced renal function, but none of children with normal kidneys. Conclusions: Children with abnormalities of a solitary kidney have often hypertension, proteinuria, or a reduced renal function. In contrast, children with healthy solitary kidneys have BP and renal function similar to those of healthy children.Keywords
This publication has 33 references indexed in Scilit:
- Low nephron number?a new cardiovascular risk factor in children?Pediatric Nephrology, 2004
- Renal length and inulin clearance in the radiologically normal single kidneyPediatric Nephrology, 2003
- Ambulatory blood pressure pediatric patientThe Journal of Pediatrics, 2000
- ASSOCIATED UROLOGICAL ANOMALIES IN CHILDREN WITH UNILATERAL RENAL AGENESISJournal of Urology, 1999
- Oscillometric twenty-four-hour ambulatory blood pressure values in healthy children and adolescents: A multicenter trial including 1141 subjectsThe Journal of Pediatrics, 1997
- Smoothing reference centile curves: The lms method and penalized likelihoodStatistics in Medicine, 1992
- Progressive renal failure in a patient after one and two-thirds nephrectomyJournal of Molecular Medicine, 1988
- Progressive renal failure in a remnant kidney.BMJ, 1985
- Mild proteinuria in patients with unilateral kidneyJournal of Molecular Medicine, 1985
- Incidence of Radiographically Evident Bone Disease, Nephrocalcinosis, and Nephrolithiasis in Various Types of Renal Tubular AcidosisThe New England Journal of Medicine, 1982