Drug-Induced Psychosis in Parkinson Disease
- 1 September 2005
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Clinical Neuropharmacology
- Vol. 28 (5), 215-219
- https://doi.org/10.1097/01.wnf.0000180228.77802.32
Abstract
To describe further the phenomenology of drug-induced psychosis (DIP) in patients with Parkinson disease (PD) and assess which items on two common psychosis rating instruments-the Brief Psychiatric Rating Scale (BPRS) and the Neuropsychiatric Inventory (NPI)-are the best measure of DIP by comparing them with the Clinical Global Impression Scale (CGIS). Baseline data from two placebo-controlled, double-blind studies of olanzapine in PD patients with DIP were collected and analyzed. A total of 157 of 160 patients had hallucinations, with visual hallucinations being the most common (97% of subjects), followed by auditory (48%), tactile (23%), and olfactory (16%). Seventy-six percent of subjects experienced delusions, and all types of delusions occurred with relatively equal frequency. The CGIS correlated with suspiciousness, hallucinatory behavior, unusual thought content, and hostility on the BPRS; and delusions, hallucinations, agitation, aberrant motor behavior, and sleep on the NPI. Nonvisual hallucinations and delusions may occur more frequently in DIP than previously thought. These symptoms, plus agitation and hostility, may ultimately be the best measure of DIP in patients with PD.Keywords
This publication has 15 references indexed in Scilit:
- Hallucinations and sleep disorders in PDNeurology, 2005
- Psychiatric comorbidities in patients with Parkinson disease and psychosisNeurology, 2004
- Prospective study of hallucinations and delusions in Parkinson's diseaseJournal of Neurology, Neurosurgery & Psychiatry, 2001
- Hallucinations in Parkinson's disease: Prevalence, phenomenology and risk factorsBrain, 2000
- Hallucinosis in idiopathic Parkinson's diseaseJournal of Neurology, Neurosurgery & Psychiatry, 1997
- Visual Hallucinations Associated With Parkinson DiseaseArchives of Neurology, 1996
- Clozapine for acute and maintenance treatment of psychosis in Parkinson's diseaseThe Journal of Neuropsychiatry and Clinical Neurosciences, 1995
- The Neuropsychiatric InventoryNeurology, 1994
- Psychosis and Other Psychiatric Manifestations of Levodopa TherapyArchives of Neurology, 1970
- The Brief Psychiatric Rating ScalePsychological Reports, 1962