Intracoronary Gene Delivery of the Cytoprotective Factor Vascular Endothelial Growth Factor-B167 in Canine Patients with Dilated Cardiomyopathy: A Short-Term Feasibility Study
Open Access
- 6 March 2019
- journal article
- conference paper
- Published by MDPI AG in Veterinary Sciences
- Vol. 6 (1), 23
- https://doi.org/10.3390/vetsci6010023
Abstract
Dilated cardiomyopathy (DCM) is a myocardial disease of dogs and humans characterized by progressive ventricular dilation and depressed contractility and it is a frequent cause of heart failure. Conventional pharmacological therapy cannot reverse the progression of the disease and, in humans, cardiac transplantation remains the only option during the final stages of heart failure. Cytoprotective gene therapy with vascular endothelial growth factor-B167 (VEGF-B167) has proved an effective alternative therapy, halting the progression of the disease in experimental studies on dogs. The aim of this work was to test the tolerability and feasibility of intracoronary administration, under fluoroscopic guidance, of VEGF-B167 carried by adeno-associated viral vectors in canine DCM patients. Ten patients underwent the gene delivery procedure. The intraoperative phase was well tolerated by all dogs. Clinical and echocardiographic assessments at 7- and 30-days post-procedure showed stable conditions compared to the pre-procedure phase. The results of this work indicate that intracoronary VEGF-B167 gene delivery is feasible and tolerated in dogs with DCM. Further monitoring/investigations are ongoing to evaluate the effects of this therapy on disease progression.Keywords
This publication has 29 references indexed in Scilit:
- Efficacy of Pimobendan in the Prevention of Congestive Heart Failure or Sudden Death in Doberman Pinschers with Preclinical Dilated Cardiomyopathy (The PROTECT Study)Journal of Veterinary Internal Medicine, 2012
- Intramyocardial VEGF-B 167 Gene Delivery Delays the Progression Towards Congestive Failure in Dogs With Pacing-Induced Dilated CardiomyopathyCirculation Research, 2010
- Vascular Endothelial Growth Factor-B Induces Myocardium-Specific Angiogenesis and Arteriogenesis via Vascular Endothelial Growth Factor Receptor-1– and Neuropilin Receptor-1–Dependent MechanismsCirculation, 2009
- Canine dilated cardiomyopathy: a retrospective study of signalment, presentation and clinical findings in 369 casesJournal of Small Animal Practice, 2009
- Effect of Pimobendan on Case Fatality Rate in Doberman Pinschers with Congestive Heart Failure Caused by Dilated CardiomyopathyJournal of Veterinary Internal Medicine, 2008
- Bone marrow cells recruited through the neuropilin-1 receptor promote arterial formation at the sites of adult neoangiogenesis in miceJCI Insight, 2008
- VEGF-B inhibits apoptosis via VEGFR-1–mediated suppression of the expression of BH3-only protein genes in mice and ratsJCI Insight, 2008
- Heart Disease and Stroke Statistics—2008 UpdateCirculation, 2008
- A Double‐Blind, Randomized, Placebo‐Controlled Study of Pimobendan in Dogs with Dilated CardiomyopathyJournal of Veterinary Internal Medicine, 2002
- A Double-Blind, Randomized, Placebo-Controlled Study of Pimobendan in Dogs with Dilated CardiomyopathyJournal of Veterinary Internal Medicine, 2002