Redox modification of proteins as essential mediators of CNS autophagy and mitophagy
Open Access
- 14 June 2013
- journal article
- review article
- Published by Wiley in FEBS Letters
- Vol. 587 (15), 2291-2298
- https://doi.org/10.1016/j.febslet.2013.06.007
Abstract
Production of cellular reactive oxygen species (ROS) is typically associated with protein and DNA damage, toxicity, and death. However, ROS are also essential regulators of signaling and work in concert with redox‐sensitive proteins to regulate cell homeostasis during stress. In this review, we focus on the redox regulation of mitophagy, a process that contributes to energetic tone as well as mitochondrial form and function. Mitophagy has been increasingly implicated in diseases including Parkinson's, Amyotrophic Lateral Sclerosis, and cancer. Although these disease states employ different genetic mutations, they share the common factors of redox dysregulation and autophagic signaling. This review highlights key redox sensitive signaling molecules which can enhance neuronal survival by promoting temporally and spatially controlled autophagic signaling and mitophagy.Keywords
This publication has 98 references indexed in Scilit:
- Complex Inhibitory Effects of Nitric Oxide on AutophagyMolecular Cell, 2011
- Nix is a selective autophagy receptor for mitochondrial clearanceEMBO Reports, 2009
- Atg32 Is a Mitochondrial Protein that Confers Selectivity during MitophagyDevelopmental Cell, 2009
- Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase PathwayMolecular Cell, 2008
- FoxO transcription factors in the maintenance of cellular homeostasis during agingCurrent Opinion in Cell Biology, 2008
- Identification of Protein Targets of 4-Hydroxynonenal Using Click Chemistry for ex Vivo Biotinylation of Azido and Alkynyl DerivativesChemical Research in Toxicology, 2008
- AKT/PKB Signaling: Navigating DownstreamCell, 2007
- Autophagy: molecular machinery for self-eatingCell Death & Differentiation, 2005
- The role of autophagy during the early neonatal starvation periodNature, 2004
- Measuring reactive species and oxidative damagein vivoand in cell culture: how should you do it and what do the results mean?British Journal of Pharmacology, 2004