Recent insights into the epidemiology and genetics of Ascaris in China using molecular tools
- 19 October 2006
- journal article
- review article
- Published by Cambridge University Press (CUP) in Parasitology
- Vol. 134 (3), 325-330
- https://doi.org/10.1017/s0031182006001521
Abstract
Ascaris is a large parasitic roundworm (nematode) of the small intestine of humans and pigs, which causes the socio-economically important disease, ascariasis. To better understand the relationship of Ascaris between the 2 host species, recent studies in China have focused on investigating the genetics and epidemiology of Ascaris from humans and pigs using a mutation scanning-based approach. Findings provided support for a low level of gene flow between the human and porcine Ascaris populations. Extending the studies of genotypic variability within Ascaris from humans and pigs, experimental infections of mice and pigs with selected genotypes of Ascaris were carried out. Initial results indicate that there is a significant difference in the ability of Ascaris eggs of genotype G1 (derived from human) and G3 (derived from pig) to infect and establish as adults in pigs, supporting the difference in the frequencies of these genotypes in natural Ascaris populations between pigs and humans in China. Taken together, current information supports that there is limited cross-infection of Ascaris between humans and pigs in endemic regions and that pigs are not a significant reservoir of human infection with the adult nematode in such areas.Keywords
This publication has 28 references indexed in Scilit:
- The development of a mouse model to explore resistance and susceptibility to early Ascaris suum infectionParasitology, 2005
- Ascariasis Is a Zoonosis in DenmarkJournal of Clinical Microbiology, 2005
- Molecular epidemiological investigation of Ascaris genotypes in China based on single‐strand conformation polymorphism analysis of ribosomal DNAElectrophoresis, 2003
- Species-specific proteins identified in Ascaris lumbricoides and Ascaris suum using two-dimensional electrophoresisZeitschrift für Parasitenkunde, 2002
- Characterisation of Ascaris from human and pighosts by nuclear ribosomal DNA sequencesInternational Journal for Parasitology, 1999
- Host specificity, evolutionary relationships and macrogeographic differentiation among Ascaris populations from humans and pigsParasitology, 1997
- Ascaris, people and pigs in a rural community of Jiangxi Province, ChinaParasitology, 1996
- Ascaris infections in humans from North America: molecular evidence for cross-infectionParasitology, 1995
- Mitochondrial DNA andAscarismicroepidemiology: the composition of parasite populations from individual hosts, families and villagesParasitology, 1995
- Value of the specific distinction between Ascaris lumbricoïdes linné 1758 and Ascaris suum Goeze 1782International Journal for Parasitology, 1973