Genetic networks responsive to sodium butyrate in colonic epithelial cells
Open Access
- 27 April 2006
- journal article
- Published by Wiley in FEBS Letters
- Vol. 580 (13), 3035-3041
- https://doi.org/10.1016/j.febslet.2006.04.048
Abstract
We performed microarray and computational gene network analyses to identify the detailed mechanisms by which sodium butyrate (SB) induces cell growth arrest and the differentiation of mouse colonic epithelial MCE301 cells. Two thousand six hundred four differentially expressed probe sets were identified in the cells treated with 2 mM SB and were classified into four groups. Of these, the gradually increased group and the gradually and remarkably decreased group contained the genetic networks for cellular development and cell cycles or canonical pathways for fatty acid biosynthesis and pyrimidine metabolism, respectively. The present results provide a basis for understanding the detailed molecular mechanisms of action of SB in colonic epithelial cells.Keywords
This publication has 37 references indexed in Scilit:
- Inhibition of Histone Deacetylase Activity by ButyrateJournal of Nutrition, 2003
- Expression profiling of CC531 colon carcinoma cells reveals similar regulation of ?-catenin target genes by both butyrate and aspirinInternational Journal of Cancer, 2003
- Transcriptional Response of a Human Colon Adenocarcinoma Cell Line to Sodium ButyrateBiochemical and Biophysical Research Communications, 2001
- Genes modulated by histone acetylation as new effectors of butyrate activityFEBS Letters, 2001
- Butyrate and trichostatin A effects on the proliferation/differentiation of human intestinal epithelial cells: induction of cyclin D3 and p21 expressionGut, 2000
- Establishment and Characterization of a Colonic Epithelial Cell Line MCE301 from Transgenic Mice Harboring Temperature-Sensitive Simian Virus 40 Large T-Antigen Gene.Cell Structure and Function, 2000
- Direct Inhibition of the Expression of Cyclin D1 Gene by Sodium ButyrateBiochemical and Biophysical Research Communications, 1996
- Effects of short chain fatty acids on gut morphology and function.Gut, 1994
- Short chain fatty acids in the human colon.Gut, 1981
- The effect of sodium butyrate on histone modificationCell, 1978