Aberrant Cdk5 Activation by p25 Triggers Pathological Events Leading to Neurodegeneration and Neurofibrillary Tangles
- 1 October 2003
- journal article
- research article
- Published by Elsevier BV in Neuron
- Vol. 40 (3), 471-483
- https://doi.org/10.1016/s0896-6273(03)00627-5
Abstract
No abstract availableKeywords
This publication has 59 references indexed in Scilit:
- Stabilization of the cyclin-dependent kinase 5 activator, p35, by paclitaxel decreases β-amyloid toxicity in cortical neuronsJournal of Neurochemistry, 2003
- The Role of Mitogen-Activated Protein Kinase Pathways in Alzheimer’s DiseaseNeurosignals, 2002
- p35/Cdk5 pathway mediates soluble amyloid‐β peptide‐induced tau phosphorylation in vitroJournal of Neuroscience Research, 2002
- Axonopathy, tau abnormalities, and dyskinesia, but no neurofibrillary tangles in p25‐transgenic miceJournal of Comparative Neurology, 2002
- Phosphorylation of MEK1 by cdk5/p35 Down-regulates the Mitogen-activated Protein Kinase PathwayPublished by Elsevier BV ,2002
- Coexpression of Human cdk5 and Its Activator p35 with Human Protein Tau in Neurons in Brain of Triple Transgenic MiceNeurobiology of Disease, 2001
- Processing of cdk5 Activator p35 to Its Truncated Form (p25) by Calpain in Acutely Injured Neuronal CellsBiochemical and Biophysical Research Communications, 2000
- Calpain-dependent Proteolytic Cleavage of the p35 Cyclin-dependent Kinase 5 Activator to p25Journal of Biological Chemistry, 2000
- Control of Memory Formation Through Regulated Expression of a CaMKII TransgeneScience, 1996
- Abnormal Alzheimer‐like phosphorylation of tau‐protein by cyclin‐dependent kinases cdk2 and cdk5FEBS Letters, 1993