Control of osteogenesis by the canonical Wnt and BMP pathways in vivo
- 29 August 2012
- Vol. 34 (11), 953-962
- https://doi.org/10.1002/bies.201200061
Abstract
Although many regulators of skeletogenesis have been functionally characterized, one current challenge is to integrate this information into regulatory networks. Here, we discuss how the canonical Wnt and Smad‐dependent BMP pathways interact together and play antagonistic or cooperative roles at different steps of osteogenesis, in the context of the developing vertebrate embryo. Early on, BMP signaling specifies multipotent mesenchymal cells into osteochondroprogenitors. In turn, the function of Wnt signaling is to drive these osteochondroprogenitors towards an osteoblastic fate. Subsequently, both pathways promote osteoblast differentiation, albeit with notable mechanistic differences. In osteocytes, the ultimate stage of osteogenic differentiation, the Wnt and BMP pathways exert opposite effects on the control of bone resorption by osteoclasts. We describe how the dynamic molecular wiring of the canonical Wnt and Smad‐dependent BMP signaling into the skeletal cell genetic programme is critical for the generation of bone‐specific cell types during development.Keywords
This publication has 107 references indexed in Scilit:
- Lineage Regulators Direct BMP and Wnt Pathways to Cell-Specific Programs during Differentiation and RegenerationCell, 2011
- PHOSPHO1 is essential for mechanically competent mineralization and the avoidance of spontaneous fracturesBone, 2011
- Msx1 and Dlx5 function synergistically to regulate frontal bone developmentgenesis, 2010
- Deciphering the genome's regulatory code: The many languages of DNABioEssays, 2010
- Identification of differentially expressed genes between osteoblasts and osteocytesBone, 2009
- Visualizing canonical Wnt signaling during mouse craniofacial developmentDevelopmental Dynamics, 2009
- Osteocytes, mechanosensing and Wnt signalingBone, 2008
- Integrating Patterning Signals: Wnt/GSK3 Regulates the Duration of the BMP/Smad1 SignalCell, 2007
- Endocrine Regulation of Energy Metabolism by the SkeletonCell, 2007
- Consequences of knocking out BMP signaling in the mousegenesis, 2002