Pathogenesis of bone erosions in rheumatoid arthritis
- 1 May 2000
- journal article
- review article
- Published by Ovid Technologies (Wolters Kluwer Health) in Current Opinion in Rheumatology
- Vol. 12 (3), 195-199
- https://doi.org/10.1097/00002281-200005000-00006
Abstract
Patients with rheumatoid arthritis are at risk for the development of a generalized form of bone loss affecting the axial and appendicular skeleton. In addition, juxta-articular osteopenia and focal erosion of marginal and subchondral bone are commonly seen. The pathogenesis of focal bone erosions is an area of active investigation. Studies of tissue sections from sites of bone erosion in rheumatoid arthritis and in animal models of inflammatory arthritis have identified multinucleated cells with the phenotype of osteoclasts in bone resorption lacunae in these sites, suggesting that osteoclasts mediate a component of this pathologic bone loss. Numerous soluble and cell-membrane factors produced by rheumatoid synovial tissues are likely to play a role in the initiation and progression of bone erosions. In addition, recent studies suggest a role for T lymphocytes and their products in osteoclast-mediated bone loss. This paper reviews the cellular mechanisms and factors implicated in bone erosions in rheumatoid arthritis, and discusses the possible therapeutic strategies suggested by these findings.Keywords
This publication has 58 references indexed in Scilit:
- Involvement of receptor activator of nuclear factor κB ligand/osteoclast differentiation factor in osteoclastogenesis from synoviocytes in rheumatoid arthritisArthritis & Rheumatism, 2000
- Activated T Lymphocytes Support Osteoclast Formation in VitroBiochemical and Biophysical Research Communications, 1999
- IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesisJCI Insight, 1999
- Osteoprotegerin Production by Human Osteoblast Lineage Cells Is Stimulated by Vitamin D, Bone Morphogenetic Protein-2, and CytokinesBiochemical and Biophysical Research Communications, 1998
- Cytokines in the pathogenesis of osteoporosisOsteoporosis International, 1997
- BONE MASS MEASUREMENT AND BONE METABOLISM IN RHEUMATOID ARTHRITIS: A REVIEWRheumatology, 1996
- Molecular Cloning of Human cDNA for Cathepsin K: Novel Cysteine Proteinase Predominantly Expressed in BoneBiochemical and Biophysical Research Communications, 1995
- LOCALIZATION OF INTERLEUKIN-1α, TYPE 1 INTERLEUKIN-1 RECEPTOR AND INTERLEUKIN-1 RECEPTOR ANTAGONIST IN THE SYNOVIAL MEMBRANE AND CARTILAGE/PANNUS JUNCTION IN RHEUMATOID ARTHRITISRheumatology, 1992
- The progression of erosion and joint space narrowing scores in rheumatoid arthritis during the first twenty‐five years of diseaseArthritis & Rheumatism, 1991
- Local and Systemic Factors in the Pathogenesis of OsteoporosisThe New England Journal of Medicine, 1988