TGF-β signaling in cancer – a double-edged sword
- 1 November 2001
- journal article
- review article
- Published by Elsevier BV in Trends in Cell Biology
- Vol. 11 (11), S44-S51
- https://doi.org/10.1016/s0962-8924(01)02130-4
Abstract
Transforming growth factor (TGF) β1 is a potent growth inhibitor, with tumor-suppressing activity. Cancers are often refractile to this growth inhibition either because of genetic loss of TGF-β signaling components or, more commonly, because of downstream perturbation of the signaling pathway, such as by Ras activation. Carcinomas often secrete excess TGF-β1 and respond to it by enhanced invasion and metastasis. Therapeutic approaches should aim to inhibit the TGF-β-induced invasive phenotype, but also to retain its growth-inhibitory and apoptosis-inducing effects.Keywords
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