Remote control of therapeutic T cells through a small molecule–gated chimeric receptor
- 16 October 2015
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 350 (6258), aab4077
- https://doi.org/10.1126/science.aab4077
Abstract
Keeping a leash on cancer-killing cells: Redirecting the immune system to attack tumor cells is proving to be an effective therapy against cancer. However, when patients are exposed to T cells engineered to recognize and attack cancer cells, there is a risk of runaway or excessive activity or of off-target effects, both of which can themselves be deadly. Wu et al. designed T cells expressing chimeric antigen receptors that recognize and attack cancer cells with an additional control system. This mechanism would allow a doctor administering the therapy to turn the engineered T cell “on” or “off” by administering a small molecule that is required along with cancer cell antigen to stimulate the T cells and activate their tumor cell–killing properties. Science , this issue p. 10.1126/science.aab4077Keywords
Funding Information
- NIH (F32 GM101782, PN2 EY016546, P50 GM081879, R01 GM055040, R01 CA196277)
- Jane Coffin Childs Memorial Fund (A121505)
- HHMI
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