Cerebral Vasomotor Responsiveness During 100% Oxygen Inhalation in Cerebral Ischemia
- 1 May 1983
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Neurology
- Vol. 40 (5), 271-276
- https://doi.org/10.1001/archneur.1983.04050050039004
Abstract
• Cerebral vasoconstrictor responsiveness to 100% oxygen inhalation was measured in 149 subjects, including normal healthy volunteers and those with risk factors for cerebral arteriosclerosis (N = 87). Test results were compared among patients with hemispheric stroke and vertebrobasilar insufficiency (N = 62) with the133Xe inhalation method. Normal volunteers without risk factors (N = 49), aged 25 to 86 years, showed symmetrical vasoconstriction. Asymptomatic subjects with risk factors (N = 38) and those with vertebrobasilar insufficiency (N = 25) had decreased hemispheric gray matter flow (Fg) values during rest, but vasoconstrictor responsiveness to 100% oxygen inhalation was not significantly reduced. In patients with acute hemispheric infarction, regional vasoconstrictor responsiveness to 100% oxygen inhalation was lost and/or paradoxically reversed; in patients with chronic hemispheric infarction, it was decreased. Testing vasomotor responses during hyperoxia is safe, clinically helpful, and demonstrates impaired vasomotor reactivity in infarcted regions.Keywords
This publication has 18 references indexed in Scilit:
- Prostaglandin Inhibition and Cerebrovascular Control in Patients with HeadacheHeadache: The Journal of Head and Face Pain, 1982
- Hyperbaric oxygenation as an adjunct therapy in strokes due to thrombosis. A review of 122 patients.Stroke, 1980
- Pathogenesis of Transient Ischemic Attacks Within the Vertebrobasilar Arterial SystemArchives of Neurology, 1979
- Effects of Inhalation of Oxygen on Blood Flow and Microvasculature of Ischemic and Nonischemic Cerebral CortexStroke, 1970
- Effects of oxygen tension on vascular and other smooth muscleThe Journal of Physiology, 1966
- TREATMENT OF FOCAL CEREBRAL ISCHEMIA WITH HYPERBARIC OXYGENActa Neurologica Scandinavica, 1965
- Transport of gases through brain and their extravascular vasomotor actionExperimental Neurology, 1961
- EFFECTS OF CARBON DIOXIDE ON THE CARDIOVASCULAR SYSTEMAnesthesiology, 1960
- CEREBRAL CIRCULATION AND METABOLISM IN SICKLE CELL AND OTHER CHRONIC ANEMIAS, WITH OBSERVATIONS ON THE EFFECTS OF OXYGEN INHALATION 1JCI Insight, 1952
- THE EFFECTS OF ALTERED ARTERIAL TENSIONS OF CARBON DIOXIDE AND OXYGEN ON CEREBRAL BLOOD FLOW AND CEREBRAL OXYGEN CONSUMPTION OF NORMAL YOUNG MEN 1JCI Insight, 1948