The role of microRNA in modulating myocardial ischemia-reperfusion injury
- 1 May 2011
- journal article
- review article
- Published by American Physiological Society in Physiological Genomics
- Vol. 43 (10), 534-542
- https://doi.org/10.1152/physiolgenomics.00130.2010
Abstract
MicroRNAs (miRNAs) are small (∼22 nt) noncoding single-stranded RNA molecules that downregulate gene expression. Studies have shown that miRNAs control diverse aspects of heart disease, including hypertrophy, remodeling, heart failure, and arrhythmia. Recently, several studies have suggested that miRNAs contribute to ischemia-reperfusion injury by altering key signaling elements, thus making them potential therapeutic targets. By altering the expression of various key elements in cell survival and apoptosis [such as phosphoinositide 3-kinase (PI3K), phosphatase and tensin homolog deleted on chromosome 10 (PTEN), Bcl-2, Mcl-1, heat shock protein (HSP)60, HSP70, HSP20, programmed cell death 4 (Pdcd4), LRRFIP1, Fas ligand (FasL), Sirt-1, etc.], miRNAs alter the response to ischemia-reperfusion injury. Studies using various in vivo, ex vivo, and in vitro models have suggested the possible involvement of miR-1, miR-21, miR-29, miR-92a, miR-133, miR-199a, and miR-320 in ischemia-reperfusion injury and/or remodeling after myocardial infarction. Thus miRNAs could be potential therapeutic targets for the treatment of heart disease. Inhibiting miRNAs by antisense strategies or pharmacological approaches is likely to emerge as an alternative and safe method for conferring short- and intermediate-term protection against ischemia-reperfusion injury.Keywords
This publication has 49 references indexed in Scilit:
- Circulating microRNAs are new and sensitive biomarkers of myocardial infarctionEuropean Heart Journal, 2010
- A translational study of circulating cell-free microRNA-1 in acute myocardial infarctionClinical Science, 2010
- MicroRNAs miR-1, miR-133a, miR-133b and miR-208 Are Dysregulated in Human Myocardial InfarctionCardiology, 2009
- MicroRNA-92a Controls Angiogenesis and Functional Recovery of Ischemic Tissues in MiceScience, 2009
- MicroRNA-21 protects against the H2O2-induced injury on cardiac myocytes via its target gene PDCD4Journal of Molecular and Cellular Cardiology, 2009
- The Emerging Role of MicroRNAs in Cardiac Remodeling and Heart FailureCirculation Research, 2008
- MicroRNAs in the broken heartEuropean Journal of Clinical Investigation, 2007
- MicroRNAs Are Aberrantly Expressed in Hypertrophic Heart: Do They Play a Role in Cardiac Hypertrophy?The American Journal of Pathology, 2007
- MicroRNAs: Genomics, Biogenesis, Mechanism, and FunctionCell, 2004
- Ischemic Preconditioning at a DistanceCirculation, 1997