Aminoglycoside Ototoxicity: A Human Temporal Bone Study
- 1 October 2001
- journal article
- case report
- Published by Wiley in The Laryngoscope
- Vol. 111 (10), 1797-1805
- https://doi.org/10.1097/00005537-200110000-00025
Abstract
Hearing loss after aminoglycoside administration has been thought to result primarily from hair cell injury. The purpose of the study was to determine the potential for direct injury of spiral ganglion cells and hair cells in cases of documented human aminoglycoside ototoxicity. Retrospective case review. The clinical course of two individuals with aminoglycoside ototoxicity are documented, including the details of administration of tobramycin and other ototoxic medication and serial audiograms. The temporal bones were processed, and the cochlear elements quantified. Histopathological study of the temporal bones from the individuals in the study demonstrated reduction of both ganglion cell and hair cell populations. Spiral ganglion cell loss was not necessarily subadjacent to areas of hair cell loss in cases of aminoglycoside ototoxicity. Instead, spiral ganglion cell reduction may be present in segments of the cochlea with normal-appearing hair cells. The study suggests that aminoglycoside antibiotics can injure spiral ganglion cells directly, as well as hair cells. Thus, the characteristic hearing loss of ototoxicity can result from degeneration of either cochlear element.Keywords
This publication has 30 references indexed in Scilit:
- Cochlear Neural Degeneration Without Hair Cell Loss in Two Patients with Aminoglycoside OtotoxicityThe Journal of Infectious Diseases, 1987
- Profound Sensorineural Deafness: A Histopathologic StudyAnnals of Otology, Rhinology & Laryngology, 1987
- Comparative ototoxicity of netilmicin, gentamicin, and tobramycin in catsToxicology and Applied Pharmacology, 1985
- HISTOPATHOLOGY OF PROFOUND SENSORINEURAL DEAFNESSaAnnals of the New York Academy of Sciences, 1983
- Inner ear histopathology in patients treated with Cis‐Platinum.The Laryngoscope, 1982
- Comparative ototoxicity of amikacin, gentamicin, netilmicin, and tobramycin in guinea pigsToxicology and Applied Pharmacology, 1982
- Evaluation of Ototoxicity of Aminoglycoside Antibiotics in RabbitsAuris Nasus Larynx, 1982
- The Comparative Ototoxicities of Gentamicin, Tobramycin and Dibekacin in the Guinea Pig A Functional and Morphological Cochlear and Vestibular StudyActa Oto-Laryngologica, 1982
- Ototoxicity of Ethacrynic Acid: Demonstrated in a Human Temporal BoneJAMA Otolaryngology–Head & Neck Surgery, 1969
- Histologische Veränderungen Des Innenohres nach Behandlung der Meningitis Tuberculosa mit StreptomycinActa Oto-Laryngologica, 1951