Suicidal risks among 2826 Sardinian major affective disorder patients
- 24 August 2007
- journal article
- Published by Wiley in Acta Psychiatrica Scandinavica
- Vol. 116 (6), 419-428
- https://doi.org/10.1111/j.1600-0447.2007.01066.x
Abstract
We estimated risks of suicidal behaviors in 2826 mood-disorder patients evaluated and followed in a Sardinian mood disorders research center over the past 30 years.We determined rates of suicidal ideation, attempts, and suicides, with associated risk factors, in men and women with DSM-IV bipolar I (BP-I; n = 529), BP-II; (n = 314), or major depressive disorders (MDD; n = 1983), at risk for an average of 11 years of illness.Observed rates (% of patients/year) of suicide ranked: BP-II (0.16) > or = BP-I (0.14) > MDD (0.05); attempts: BP-I (1.52) > BP-II (0.82) > MDD (0.48); ideation: BP-II (42.7) > MDD (33.8) > BP-I (22.7). The ratio of attempts/suicides (lethality index) ranked: BP-II (5.12) < MDD (9.60) < or = BP-I (10.8). Male/female risk-ratios were greater for suicide than attempts or ideation. One-third of all reported acts occurred within the first year of illness, and earliest among MDD patients. Factors associated independently with suicidal acts included BP diagnosis, hospitalizations/person, and early illness-onset; factors associated with suicidal ideation were having an affective temperament, BP-II diagnosis, and higher suicidality-corrected depression score at intake.Suicidal behaviors were more prevalent among BPD than MDD out-patients.Keywords
This publication has 45 references indexed in Scilit:
- DuloxetineJournal of Clinical Psychopharmacology, 2006
- Suicide Rates in Relation to Health Care Access in the United StatesBritish Journal of Psychology, 2006
- Suicide Rates in Short-term Randomized Controlled Trials of Newer AntidepressantsJournal of Clinical Psychopharmacology, 2006
- Psychopathologic Correlates of Suicidal Ideation in Major Depressive Outpatients: Is It All Due to Unrecognized (Bipolar) Depressive Mixed States?Psychopathology, 2005
- Suicide in 406 Mood-Disorder Patients With and Without Long-Term Medication: A 40 to 44 Years' Follow-UpArchives of Suicide Research, 2005
- Association between suicide attempts and selective serotonin reuptake inhibitors: systematic review of randomised controlled trialsBMJ, 2005
- Selective serotonin reuptake inhibitors (SSRIs) and suicide in adults: meta-analysis of drug company data from placebo controlled, randomised controlled trials submitted to the MHRA's safety reviewBMJ, 2005
- Affective Disorders and Suicide Risk: A ReexaminationAmerican Journal of Psychiatry, 2000
- Survival analysis of suicide risk after attempted suicideActa Psychiatrica Scandinavica, 1995
- Mortality in major affective disorder: relationship to subtype of depressionActa Psychiatrica Scandinavica, 1993