Erectile dysfunction prospectively associated with cardiovascular disease in the Dutch general population: results from the Krimpen Study
- 30 August 2007
- journal article
- Published by Springer Science and Business Media LLC in International Journal Of Impotence Research
- Vol. 20 (1), 92-99
- https://doi.org/10.1038/sj.ijir.3901604
Abstract
The possible relationship between erectile dysfunction and the later occurrence of cardiovascular disease while biologically plausible has been evaluated in only a few studies. Our objective is to determine the relation between ED as defined by a single question on erectile rigidity and the later occurrence of myocardial infarction, stroke and sudden death in a population-based cohort study. In Krimpen aan den IJssel, a municipality near Rotterdam, all men aged 50–75 years, without cancer of the prostate or the bladder, without a history of radical prostectomy, neurogenic bladder disease, were invited to participate for a response rate of 50%. The answer to a single question on erectile rigidity included in the International Continence Society male sex questionnaire was used to define the severity of erectile dysfunction at baseline. Data on cardiovascular risk factors at baseline (age smoking, blood pressure, total- and high-density lipoprotein cholesterol, diabetes) were used to calculate Framingham risk scores. During an average of 6.3 years of follow-up, cardiovascular end points including acute myocardial infarction, stroke and sudden death were determined. Of the 1248 men free of CVD at baseline, 258 (22.8%) had reduced erectile rigidity and 108 (8.7%) had severely reduced erectile rigidity. In 7945 person-years of follow-up, 58 cardiovascular events occurred. In multiple variable Cox proportional hazards model adjusting for age and CVD risk score, hazard ratio was 1.6 (95% confidence interval (CI): 1.2–2.3) for reduced erectile rigidity and 2.6 (95% CI: 1.3–5.2) for severely reduced erectile rigidity. The population attributable risk fraction for reduced and severely reduced erectile rigidity was 11.7%. In this population-based study, a single question on erectile rigidity proved to be a predictor for the combined outcome of acute myocardial infarction, stroke and sudden death, independent of the risk factors used in the Framingham risk profile.This publication has 32 references indexed in Scilit:
- Sexual Dysfunction and Cardiac Risk (the Second Princeton Consensus Conference)The American Journal of Cardiology, 2005
- Re: Ebert T, Jockenhövel F, Morales A, Shabsigh R. The current status of therapy for symptomatic late onset hypogonadism with transdermal testosterone gel. Eur Urol 2005;47:137–46European Urology, 2005
- Loss to Follow-Up in a Longitudinal Study on Urogenital Tract Symptoms in Dutch Older MenUrologia Internationalis, 2005
- Incidence rates of erectile dysfunction in the Dutch general population. Effects of definition, clinical relevance and duration of follow-up in the Krimpen StudyInternational Journal Of Impotence Research, 2004
- The way I see it: House officers need formal career developmentBMJ, 2002
- Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patientsBMJ, 2002
- Strong effects of definition and nonresponse bias on prevalence rates of clinical benign prostatic hyperplasia: the Krimpen study of male urogenital tract problems and general health statusBJU International, 2000
- INCIDENCE OF ERECTILE DYSFUNCTION IN MEN 40 TO 69 YEARS OLD:Journal of Urology, 2000
- A new drug classification for computer systems: the ATC extension codeInternational Journal of Bio-Medical Computing, 1995
- Cardiovascular disease risk profilesAmerican Heart Journal, 1991