Glatiramer acetate reduces the proportion of new MS lesions evolving into “black holes”
- 28 August 2001
- journal article
- Published by Ovid Technologies (Wolters Kluwer Health) in Neurology
- Vol. 57 (4), 731-733
- https://doi.org/10.1212/wnl.57.4.731
Abstract
The authors evaluated whether glatiramer acetate (GA) modifies the severity of tissue damage in 1,722 new lesions from 239 patients with MS enrolled in a placebo-controlled trial monitored with monthly cerebral MRI. The percentage of new lesions that evolved into “black holes” was lower in GA-treated than in placebo patients on scans at 7 (18.9 and 26.3%; p = 0.04) and 8 (15.6 and 31.4%; p = 0.002) months after lesion appearance. GA has a favorable effect on tissue disruption in MS lesions once they are formed.Keywords
This publication has 9 references indexed in Scilit:
- European/Canadian multicenter, double‐blind, randomized, placebo‐controlled study of the effects of glatiramer acetate on magnetic resonance imaging–measured disease activity and burden in patients with relapsing multiple sclerosisAnnals of Neurology, 2001
- P81 – P162Neuroimmunomodulation, 1999
- Neuronal damage in T1-hypointense multiple sclerosis lesions demonstrated in vivo using proton magnetic resonance spectroscopyAnnals of Neurology, 1999
- Magnetic resonance outcome of new enhancing lesions in patients with relapsing‐remitting multiple sclerosisEuropean Journal of Neurology, 1999
- Bystander suppression of experimental autoimmune encephalomyelitis by T cell lines and clones of the Th2 type induced by copolymer 1Journal of Neuroimmunology, 1998
- Axonal Transection in the Lesions of Multiple SclerosisNew England Journal of Medicine, 1998
- Inflammatory central nervous system demyelination: Correlation of magnetic resonance imaging findings with lesion pathologyAnnals of Neurology, 1997
- Correlating MRI and clinical disease activity in multiple sclerosisNeurology, 1995
- Copolymer 1 reduces relapse rate and improves disability in relapsing‐remitting multiple sclerosisNeurology, 1995