Animal models for the atherosclerosis research: a review
- 1 March 2011
- journal article
- review article
- Published by Springer Science and Business Media LLC in Protein & Cell
- Vol. 2 (3), 189-201
- https://doi.org/10.1007/s13238-011-1016-3
Abstract
Atherosclerosis is a leading cause of death worldwide, and its mechanisms are still unclear. However, various animal models have significantly advanced our understanding of the mechanisms involved in atherosclerosis and have allowed the evaluation of therapeutic options. The aim of this paper is to review those animal models (i.e., rabbits, mice, rats, guinea pigs, hamsters, avian, carnivores, swine, and, non-human primates) that have been used to study atherosclerosis. Though there is no single perfect animal model that completely replicates the stages of human atherosclerosis, cholesterol feeding and mechanical endothelial injury are two common features shared by most models of atherosclerosis. Further, with the development of genetically modified animals, these models are significantly broadening our understanding of the pathogenesis of atherosclerosis.Keywords
This publication has 128 references indexed in Scilit:
- Use of hamster as a model to study diet-induced atherosclerosisNutrition & Metabolism, 2010
- Inflammation, Atherosclerosis, and Coronary Artery DiseaseThe New England Journal of Medicine, 2005
- Chronic Kidney Disease and the Risks of Death, Cardiovascular Events, and HospitalizationThe New England Journal of Medicine, 2004
- Stabilization of atherosclerotic plaques: New mechanisms and clinical targetsNature Medicine, 2002
- Mechanisms of bioprosthetic heart valve failure: Fatigue causes collagen denaturation and glycosaminoglycan lossJournal of Biomedical Materials Research, 1999
- Overexpression of Human Apolipoprotein B-100 in Transgenic Rabbits Results in Increased Levels of LDL and Decreased Levels of HDLArteriosclerosis, Thrombosis, and Vascular Biology, 1995
- The pathogenesis of atherosclerosis: a perspective for the 1990sNature, 1993
- Lipoprotein and apoprotein profile of Japanese quailBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1993
- Spontaneous Hypercholesterolemia and Arterial Lesions in Mice Lacking Apolipoprotein EScience, 1992
- Intravenous TrypsinCirculation, 1954