Outcomes following endoscopic, expanded endonasal resection of suprasellar craniopharyngiomas: a case series
- 1 July 2008
- journal article
- Published by Journal of Neurosurgery Publishing Group (JNSPG) in Journal of Neurosurgery
- Vol. 109 (1), 6-16
- https://doi.org/10.3171/jns/2008/109/7/0006
Abstract
Craniopharyngiomas are challenging tumors that most frequently occur in the sellar or suprasellar regions. Microscopic transsphenoidal resections with various extensions and variations have been performed with good results. The addition of the endoscope as well as the further expansion of the standard and extended transsphenoidal approaches has not been well evaluated for the treatment of this pathological entity. The authors performed a retrospective review of all patients who underwent a purely endoscopic, expanded endonasal approach (EEA) for the resection of craniopharyngiomas at their institution between June 1999 and February 2006. Endocrine and ophthalmological outcomes, extent of resection, and complications were evaluated. Sixteen patients underwent endoscopic EEA for the resection of craniopharyngiomas. Five patients (31%) presented with recurrent disease. Complete resection was planned in 11 of the 16 patients. Three elderly patients with vision loss underwent planned debulking, 1 patient with vision loss and a moderate-sized tumor had express wishes for debulking, and 1 patient had a separate, third ventricular nodule that was not resected. Of those in whom complete resection was planned, 91% underwent near-total (2/11) or gross-total (8/11) resection. No patient who underwent gross-total resection suffered a recurrence. The mean follow-up period was 34 months. Of the 14 patients who presented with vision loss, 93% had improvement or complete recovery and 1 patient's condition remained stable. No patient experienced visual worsening. Eighteen percent of patients (without preexisting hypopituitarism) developed panhypopituitarism and 8% developed permanent diabetes insipidus. There were no cases of new obesity. The postoperative cerebrospinal fluid leak rate was 58%. All leaks were resolved, and there were no cases of bacterial meningitis. There was 1 vascular injury (posterior cerebral artery perforator branch) resulting in the only new neurological deficit. No patient died. Endoscopic EEA for the resection of craniopharyngiomas provides acceptable results and holds the potential to improve outcomes.Keywords
This publication has 32 references indexed in Scilit:
- Surgical outcomes in 31 patients with craniopharyngiomas extending outside the suprasellar cistern: an evaluation of the frontobasal interhemispheric approachJournal of Neurosurgery, 2002
- Transsphenoidal Approaches for the Extracapsular Resection of Midline Suprasellar and Anterior Cranial Base LesionsNeurosurgery, 2001
- Resection of suprasellar tumors by using a modified transsphenoidal approachJournal of Neurosurgery, 2000
- Selective excision of adenomas originating in or extending into the pituitary stalk with preservation of pituitary functionJournal of Neurosurgery, 1997
- Management of childhood craniopharyngioma: can the morbidity of radical surgery be predicted?Journal of Neurosurgery, 1996
- Surgical Treatment of CraniopharyngiomasNeurosurgery, 1995
- CraniopharyngiomasNeurosurgery, 1994
- An Approach to Radical Excision of Craniopharyngioma by the Temporal RoutePediatric Neurosurgery, 1994
- Transsphenoidal microsurgery for craniopharyngiomaSurgical Neurology, 1992
- Long Term Results in the Management of CraniopharyngiomasNeurosurgery, 1977