Improved base excision repair inhibition and bacteriophage Mu Gam protein yields C:G-to-T:A base editors with higher efficiency and product purity

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Abstract
Probing base editing outcomes leads to new C:G to T:A base editors with greater efficiency and product purity, and fewer indels.
Funding Information
  • Defense Sciences Office, DARPA (award341255, HR0011-17-2-0049)
  • HHMI (award341256, Liu Investigatorship)
  • NIBIB (award341257, R01 EB022376)
  • NIGMS (award341258, R35 GM118062)