Single-Step Synthesis of Racemic Di- and Tripeptides Derived from Unnatural β-Hydroxy and β-Mercapto α-Amino, Acids by the Ugi Reaction

Abstract

An efficient single-step selective synthesis of oligopeptide analogues, which contain amino acid analogues and are derivatives of 3-thiazolidines and 3-oxazolidine, through the use of hydrochloric acid as the protecting agent is described. These compounds are prepared based on the Ugi four component condensation (4CC) reaction.