Chondroitin sulfate N-acetylgalactosaminyltransferase-1 is required for normal cartilage development
Open Access
- 25 October 2010
- journal article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 432 (1), 47-55
- https://doi.org/10.1042/bj20100847
Abstract
CS (chondroitin sulfate) is a glycosaminoglycan species that is widely distributed in the extracellular matrix. To understand the physiological roles of enzymes involved in CS synthesis, we produced CSGalNAcT1 (CS N-acetylgalactosaminyltransferase 1)-null mice. CS production was reduced by approximately half in CSGalNAcT1-null mice, and the amount of short-chain CS was also reduced. Moreover, the cartilage of the null mice was significantly smaller than that of wild-type mice. Additionally, type-II collagen fibres in developing cartilage were abnormally aggregated and disarranged in the homozygous mutant mice. These results suggest that CSGalNAcT1 is required for normal CS production in developing cartilage.Keywords
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